The functional role of mitochondria in cell physiology has previously centered around
metabolism, with oxidative phosphorylation playing a pivotal role. Recently, however, this …

In addition to powering energy needs of the cell, mitochondria function as pivotal integrators
of cell survival/death signals. In recent years, numerous studies indicate that each of the …

Reactive oxygen species (ROS) are believed to be involved in triggering cardiac ischemic
preconditioning (IPC). Decreased formation of ROS on reperfusion after prolonged ischemia …

Carbon monoxide (CO), one of the end products of heme oxygenase activity, inhibits smooth
muscle proliferation by decreasing ERK1/2 phosphorylation andcyclin D1 expression, a …

Oxidative stress is a constant threat to all living organisms and an immense repertoire of
cellular defense systems is being employed by most pro-and eukaryotic systems to eliminate …

Mitochondria are proposed to play an important role in hypoxic cell signaling. One currently
accepted signaling paradigm is that the mitochondrial generation of reactive oxygen species …

On constate que l'apoptose, mort cellulaire programmée, est un événement cellulaire
important dans le développement normal et dans la progression de maladies spécifiques …

The toxic effects of oxidative stress on cells (including cardiac myocytes, the contractile cells
of the heart) are well known. However, an increasing body of evidence has suggested that …

The controlled formation of ROS (reactive oxygen species) and RNS (reactive nitrogen
species) is now known to be critical in cellular redox signalling. As with the more familiar …

The recent upsurge in proteomics research has been facilitated largely by streamlining of
two‐dimensional (2‐D) gel technology and the parallel development of facile mass …