Carbon-based glyco-nanoplatforms: towards the next generation of glycan-based multivalent probes

J Ramos-Soriano, M Ghirardello… - Chemical Society Reviews, 2022 - pubs.rsc.org
Cell surface carbohydrates mediate a wide range of carbohydrate–protein interactions key
to healthy and disease mechanisms. Many of such interactions are multivalent in nature and …

Synthesis and biological application of glyco-and peptide derivatives of fullerene C60

L Tanzi, M Terreni, Y Zhang - European Journal of Medicinal Chemistry, 2022 - Elsevier
Fullerenes have attracted considerable attention for their possible use in human therapy.
Pure C 60 is soluble only in some organic solvents, but this could be overcome by chemical …

Multivalent glycosylated nanostructures to inhibit Ebola virus infection

BM Illescas, J Rojo, R Delgado… - Journal of the American …, 2017 - ACS Publications
The infection of humans by lethal pathogens such as Ebola and other related viruses has
not been properly addressed so far. In this context, a relevant question arises: What can …

Glycodendritic structures as DC-SIGN binders to inhibit viral infections

J Ramos-Soriano, J Rojo - Chemical Communications, 2021 - pubs.rsc.org
DC-SIGN, a lectin discovered two decades ago, plays a relevant role in innate immunity.
Since its discovery, it has turned out to be a target for developing antiviral drugs based on …

Antiviral activity of self-assembled glycodendro [60] fullerene monoadducts

A Muñoz, BM Illescas, J Luczkowiak, F Lasala… - Journal of Materials …, 2017 - pubs.rsc.org
A series of amphiphilic glycodendro [60] fullerene monoadducts were efficiently synthesized
using the CuAAC “click chemistry” approach. These glycodendrofullerenes can self …

Multifaceted glycodendrimers with programmable bioactivity through convergent, divergent, and accelerated approaches using polyfunctional cyclotriphosphazenes

L Abbassi, YM Chabre, N Kottari, AA Arnold… - Polymer …, 2015 - pubs.rsc.org
We report the sequential construction of a set of multivalent structures using
cyclotriphosphazene (CTP) units, which were extensively used as primary or secondary …

Multivalent Tryptophan‐and Tyrosine‐Containing [60] Fullerene Hexa‐Adducts as Dual HIV and Enterovirus A71 Entry Inhibitors

M Ruiz‐Santaquiteria, BM Illescas… - … A European Journal, 2021 - Wiley Online Library
Unprecedented 3D hexa‐adducts of [60] fullerene peripherally decorated with twelve
tryptophan (Trp) or tyrosine (Tyr) residues have been synthesized. Studies on the antiviral …

Construction of giant glycosidase inhibitors from iminosugar-substituted fullerene macromonomers

TMN Trinh, M Holler, JP Schneider… - Journal of Materials …, 2017 - pubs.rsc.org
An ultra-fast synthetic procedure based on grafting of twelve fullerene macromonomers onto
a fullerene hexa-adduct core was used for the preparation of a giant molecule with 120 …

C60‐based Multivalent Glycoporphyrins Inhibit SARS‐CoV‐2 Specific Interaction with the DC‐SIGN Transmembrane Receptor

J Patino‐Alonso, J Cabrera‐González, J Merino… - Small, 2024 - Wiley Online Library
Since WHO has declared the COVID‐19 outbreak a global pandemic, nearly seven million
deaths have been reported. This efficient spread of Severe Acute Respiratory Syndrome …

Multivalent cationic dendrofullerenes for gene transfer: Synthesis and DNA complexation

BM Illescas, A Pérez-Sánchez, A Mallo… - Journal of Materials …, 2020 - pubs.rsc.org
Non-viral nucleic acid vectors able to display high transfection efficiencies with low toxicity
and overcoming the multiple biological barriers are needed to further develop the clinical …