Species of Scedosporium and Fusarium are considered emerging opportunistic pathogens,
causing invasive fungal diseases in humans that are known as scedosporiosis and …

Due to a lack of novel therapies and biomarkers, the clinical outcomes of osteosarcoma
patients have not significantly improved for decades. The advancement of mass …

Microarray compositions suitable for analysis by one or several spectrographic methods are
disclosed. In an embodiment, a microarray composition includes a three-dimensional solid …

Measurements of target activation in cells or tissues are key indicators of efficacy during
drug development. In contrast to established methods that require reagents and multiple …

The cyanobacterial toxin β-N-methylamino-l-alanine (BMAA) has been proposed to
contribute to neurodegenerative disease. We have previously reported a selective uptake of …

Background Macrophage migration inhibitory factor (MIF) is involved in the function of both
the innate and adaptive immune systems and in neuroprotection and has recently been …

Evidence is rapidly growing regarding a role of astroglial cells in the pathogenesis of
Alzheimer's disease (AD), and the hippocampus is one of the important brain regions …

We introduce single-cell Proteoform imaging Mass Spectrometry (scPiMS), which realizes
the benefit of direct analysis of intact proteins to process 10,836 single cells from the rat …

The pathological mechanisms underlying Alzheimer's disease (AD) are still not understood.
The disease pathology is characterized by the accumulation and aggregation of amyloid‐β …

Tissue-resident immune cells differ from their corresponding blood cells in many functional
aspects. Although the proteome of blood immune cells has been well-investigated, there are …