The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism.
The PPP is important to maintain carbon homoeostasis, to provide precursors for nucleotide …

Radiotherapy, an important treatment modality in oncology, kills cells through induction of
oxidative stress. However, malignant tumors vary in their response to irradiation as a …

Cancer cells experience an increase in oxidative stress. The pentose phosphate pathway
(PPP) is a major biochemical pathway that generates antioxidant NADPH. Here, we show …

It has been long recognized that cancer cells reprogram their metabolism under hypoxia
conditions due to a shift from oxidative phosphorylation (OXPHOS) to glycolysis in order to …

Metabolic adaptations are intimately associated with changes in cell behavior. Cancers are
characterized by a high metabolic plasticity resulting from mutations and the selection of …

Within the last few years, knowledge about vitamins has increased dramatically. This new
edition of a bestseller presents comprehensive summaries that analyze the chemical …

The analysis of cancer metabolome has shown that proliferating tumor cells require a large
quantities of different nutrients in order to support their high rate of proliferation. In this study …

The interest in fructose metabolism is based on the observation that an increased dietary
fructose consumption leads to an increased risk of obesity and metabolic syndrome. In …

Patients with ependymoma exhibit a wide range of clinical outcomes that are currently
unexplained by clinical or histological factors. Little is known regarding molecular …

Accumulation of nucleotide building blocks prior to and during S phase facilitates DNA
duplication. Herein, we find that the anaphase-promoting complex/cyclosome (APC/C) …