Mitochondrial fusion and fission in cell life and death

B Westermann - Nature reviews Molecular cell biology, 2010 - nature.com
Mitochondria are dynamic organelles that constantly fuse and divide. These processes
(collectively termed mitochondrial dynamics) are important for mitochondrial inheritance and …

Programmed cell death in aging

J Tower - Ageing research reviews, 2015 - Elsevier
Programmed cell death (PCD) pathways, including apoptosis and regulated necrosis, are
required for normal cell turnover and tissue homeostasis. Mis-regulation of PCD is …

Comparison of methods used for assessing the viability and vitality of yeast cells

M Kwolek-Mirek, R Zadrag-Tecza - FEMS yeast research, 2014 - academic.oup.com
Determination of cell viability is the most commonly used method for assessing the impact of
various types of stressors in toxicity research and in industrial microbiology studies. Viability …

A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity

X Qi, N Qvit, YC Su… - Journal of cell …, 2013 - journals.biologists.com
Excessive mitochondrial fission is associated with the pathology of a number of
neurodegenerative diseases. Therefore, inhibitors of aberrant mitochondrial fission could …

Mitochondrial dynamics and apoptosis

DF Suen, KL Norris, RJ Youle - Genes & development, 2008 - genesdev.cshlp.org
In healthy cells, mitochondria continually divide and fuse to form a dynamic interconnecting
network. The molecular machinery that mediates this organelle fission and fusion is …

[HTML][HTML] OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion

C Frezza, S Cipolat, OM De Brito, M Micaroni… - Cell, 2006 - cell.com
Mitochondria amplify activation of caspases during apoptosis by releasing cytochrome c and
other cofactors. This is accompanied by fragmentation of the organelle and remodeling of …

[HTML][HTML] Mechanisms of cytochrome c release from mitochondria

C Garrido, L Galluzzi, M Brunet, PE Puig… - Cell Death & …, 2006 - nature.com
In healthy cells, cytochrome c (Cyt c) is located in the mitochondrial intermembrane/
intercristae spaces, where it functions as an electron shuttle in the respiratory chain and …

The role of Drp1 in mitophagy and cell death in the heart

M Tong, D Zablocki, J Sadoshima - Journal of molecular and cellular …, 2020 - Elsevier
Maintenance of mitochondrial function and integrity is critical for normal cell survival,
particularly in non-dividing cells with a high-energy demand such as cardiomyocytes. Well …

[HTML][HTML] Inhibition of mitochondrial fragmentation diminishes Huntington's disease–associated neurodegeneration

X Guo, MH Disatnik, M Monbureau… - The Journal of …, 2013 - Am Soc Clin Investig
Huntington's disease (HD) is the result of expression of a mutated Huntingtin protein (mtHtt),
and is associated with a variety of cellular dysfunctions including excessive mitochondrial …

Causal roles of mitochondrial dynamics in longevity and healthy aging

A Sharma, HJ Smith, P Yao, WB Mair - EMBO reports, 2019 - embopress.org
Mitochondria are organized in the cell in the form of a dynamic, interconnected network.
Mitochondrial dynamics, regulated by mitochondrial fission, fusion, and trafficking, ensure …