Mitochondria are dynamic organelles that constantly fuse and divide. These processes
(collectively termed mitochondrial dynamics) are important for mitochondrial inheritance and …

Programmed cell death (PCD) pathways, including apoptosis and regulated necrosis, are
required for normal cell turnover and tissue homeostasis. Mis-regulation of PCD is …

Determination of cell viability is the most commonly used method for assessing the impact of
various types of stressors in toxicity research and in industrial microbiology studies. Viability …

Excessive mitochondrial fission is associated with the pathology of a number of
neurodegenerative diseases. Therefore, inhibitors of aberrant mitochondrial fission could …

In healthy cells, mitochondria continually divide and fuse to form a dynamic interconnecting
network. The molecular machinery that mediates this organelle fission and fusion is …

Mitochondria amplify activation of caspases during apoptosis by releasing cytochrome c and
other cofactors. This is accompanied by fragmentation of the organelle and remodeling of …

In healthy cells, cytochrome c (Cyt c) is located in the mitochondrial intermembrane/
intercristae spaces, where it functions as an electron shuttle in the respiratory chain and …

Maintenance of mitochondrial function and integrity is critical for normal cell survival,
particularly in non-dividing cells with a high-energy demand such as cardiomyocytes. Well …

Huntington's disease (HD) is the result of expression of a mutated Huntingtin protein (mtHtt),
and is associated with a variety of cellular dysfunctions including excessive mitochondrial …

Mitochondria are organized in the cell in the form of a dynamic, interconnected network.
Mitochondrial dynamics, regulated by mitochondrial fission, fusion, and trafficking, ensure …