The scaffold-forming steps of plant alkaloid biosynthesis

BR Lichman - Natural Product Reports, 2021 - pubs.rsc.org
Alkaloids from plants are characterised by structural diversity and bioactivity, and maintain a
privileged position in both modern and traditional medicines. In recent years, there have …

Biosynthesis investigations of terpenoid, alkaloid, and flavonoid antimicrobial agents derived from medicinal plants

W Huang, Y Wang, W Tian, X Cui, P Tu, J Li, S Shi… - Antibiotics, 2022 - mdpi.com
The overuse of antibiotics in the past decades has led to the emergence of a large number
of drug-resistant microorganisms. In recent years, the infection rate caused by multidrug …

The Pictet–Spengler reaction in nature and in organic chemistry

J Stöckigt, AP Antonchick, F Wu… - Angewandte Chemie …, 2011 - Wiley Online Library
Alkaloids are an important class of natural products that are widely distributed in nature and
produced by a large variety of organisms. They have a wide spectrum of biological activity …

Significance of inducible defense-related proteins in infected plants

LC van Loon, M Rep, CMJ Pieterse - Annu. Rev. Phytopathol., 2006 - annualreviews.org
Inducible defense-related proteins have been described in many plant species upon
infection with oomycetes, fungi, bacteria, or viruses, or insect attack. Several types of …

Peroxisome compartmentalization of a toxic enzyme improves alkaloid production

PS Grewal, JA Samson, JJ Baker, B Choi… - Nature Chemical …, 2021 - nature.com
Eukaryotic cells compartmentalize metabolic pathways in organelles to achieve optimal
reaction conditions and avoid crosstalk with cytosolic factors. We found that cytosolic …

Benzylisoquinoline alkaloid metabolism: a century of discovery and a brave new world

JM Hagel, PJ Facchini - Plant and Cell Physiology, 2013 - academic.oup.com
Benzylisoquinoline alkaloids (BIAs) are a structurally diverse group of plant specialized
metabolites with a long history of investigation. Although the ecophysiological functions of …

Chemistry and biology of monoterpene indole alkaloid biosynthesis

SE O'Connor, JJ Maresh - Natural product reports, 2006 - pubs.rsc.org
Chemistry and biology of monoterpene indole alkaloid biosynthesis - Natural Product Reports
(RSC Publishing) DOI:10.1039/B512615K Royal Society of Chemistry View PDF …

Subcellular compartmentalization in the biosynthesis and engineering of plant natural produces

L Yao, X Wu, X Jiang, M Shan, Z Zhang, Y Li… - Biotechnology …, 2023 - Elsevier
Plant natural products (PNPs) are specialized metabolites with diverse bioactivities. They
are extensively used in the pharmaceutical, cosmeceutical and food industries. PNPs are …

Alkaloid biosynthesis: metabolism and trafficking

J Ziegler, PJ Facchini - Annu. Rev. Plant Biol., 2008 - annualreviews.org
Alkaloids represent a highly diverse group of compounds that are related only by the
occurrence of a nitrogen atom in a heterocyclic ring. Plants are estimated to produce …

Benzylisoquinoline alkaloid biosynthesis in opium poppy

GAW Beaudoin, PJ Facchini - Planta, 2014 - Springer
Opium poppy (Papaver somniferum) is one of the world's oldest medicinal plants and
remains the only commercial source for the narcotic analgesics morphine, codeine and semi …