The physiology, pathology, and potential therapeutic applications of the TREM2 signaling pathway
Alzheimer's disease, obesity-related metabolic syndrome, and cancer are the leading
causes of death and among the most costly medical conditions in the Western world. In all …
causes of death and among the most costly medical conditions in the Western world. In all …
[HTML][HTML] Soluble TREM2: Innocent bystander or active player in neurological diseases?
Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune receptor
expressed by macrophages and microglia in the central nervous system (CNS). TREM2 has …
expressed by macrophages and microglia in the central nervous system (CNS). TREM2 has …
Systematic assessment of 10 biomarker candidates focusing on α‐synuclein‐related disorders
I Schulz, N Kruse, RG Gera, T Kremer… - Movement …, 2021 - Wiley Online Library
Background Objective diagnostic biomarkers are needed to support a clinical diagnosis.
Objectives To analyze markers in various neurodegenerative disorders to identify diagnostic …
Objectives To analyze markers in various neurodegenerative disorders to identify diagnostic …
Translational molecular imaging and drug development in Parkinson's disease
Parkinson's disease (PD) is a progressive neurodegenerative disorder that primarily affects
elderly people and constitutes a major source of disability worldwide. Notably, the …
elderly people and constitutes a major source of disability worldwide. Notably, the …
Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer's disease
Background The recent promise of disease-modifying therapies for Alzheimer's disease
(AD) has reinforced the need for accurate biomarkers for early disease detection, diagnosis …
(AD) has reinforced the need for accurate biomarkers for early disease detection, diagnosis …
[HTML][HTML] Quantifying cerebrospinal fluid dynamics: a review of human neuroimaging contributions to CSF physiology and neurodegenerative disease
Cerebrospinal fluid (CSF), predominantly produced in the ventricles and circulating
throughout the brain and spinal cord, is a key protective mechanism of the central nervous …
throughout the brain and spinal cord, is a key protective mechanism of the central nervous …
TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models
Human genetics implicate defective myeloid responses in the development of late-onset
Alzheimer disease. A decline in peripheral and brain myeloid metabolism, triggering …
Alzheimer disease. A decline in peripheral and brain myeloid metabolism, triggering …
Distinct myeloid population phenotypes dependent on TREM2 expression levels shape the pathology of traumatic versus demyelinating CNS disorders
H Gao, J Di, BH Clausen, N Wang, X Zhu, T Zhao… - Cell reports, 2023 - cell.com
Triggering receptor expressed on myeloid cell 2 (TREM2) signaling often drives opposing
effects in traumatic versus demyelinating CNS disorders. Here, we identify two distinct …
effects in traumatic versus demyelinating CNS disorders. Here, we identify two distinct …
Soluble TREM2 triggers microglial dysfunction in neuromyelitis optica spectrum disorders
C Qin, M Chen, MH Dong, S Yang, H Zhang, YF You… - Brain, 2024 - academic.oup.com
Microglia-mediated neuroinflammation contributes to acute demyelination in neuromyelitis
optica spectrum disorders (NMOSD). Soluble triggering receptor expressed on myeloid cells …
optica spectrum disorders (NMOSD). Soluble triggering receptor expressed on myeloid cells …
Limited proteolysis–mass spectrometry reveals aging-associated changes in cerebrospinal fluid protein abundances and structures
Cerebrospinal fluid (CSF) proteins and their structures have been implicated in aging and
neurodegenerative diseases. In the present study, we used limited proteolysis–mass …
neurodegenerative diseases. In the present study, we used limited proteolysis–mass …