Apoptosis or programmed cell death is a key regulator of physiological growth control and
regulation of tissue homeostasis. One of the most important advances in cancer research in …

Every cell in a multicellular organism has the potential to die by apoptosis, but tumour cells
often have faulty apoptotic pathways. These defects not only increase tumour mass, but also …

Apoptosis induced by TNF-receptor I (TNFR1) is thought to proceed via recruitment of the
adaptor FADD and caspase-8 to the receptor complex. TNFR1 signaling is also known to …

Resistance to chemotherapy limits the effectiveness of anti‐cancer drug treatment. Tumours
may be intrinsically drug‐resistant or develop resistance to chemotherapy during treatment …

Apoptosis, or programmed cell death, is a mechanism by which cells undergo death to
control cell proliferation or in response to DNA damage. The understanding of apoptosis has …

The heterotrimeric guanine nucleotide–binding proteins (G proteins) are signal transducers
that communicate signals from many hormones, neurotransmitters, chemokines, and …

Apoptosis and related forms of cell death have central importance in development,
homeostasis, tumor surveillance, and the function of the immune system. Apoptosis is …

Death receptors are members of the tumor necrosis factor receptor superfamily
characterized by a cytoplasmic region known as the “death domain” that enables the …

The death-inducing signaling complex (DISC) initiates death receptor-induced apoptosis.
DISC assembly and activation are controlled by c-FLIP isoforms, which function as pro …

Apoptosis is an evolutionary conserved homeostatic process involved in distinct
physiological processes including organ and tissue morphogenesis, development and …