Cryptococcus neoformans: historical curiosity to modern pathogen

D Srikanta, FH Santiago‐Tirado, TL Doering - Yeast, 2014 - Wiley Online Library
The importance of the Basidiomycete Cryptococcus neoformans to human health has
stimulated its development as an experimental model for both basic physiology and …

Life Cycle of Cryptococcus neoformans

Y Zhao, J Lin, Y Fan, X Lin - Annual review of microbiology, 2019 - annualreviews.org
Cryptococcus neoformans is a ubiquitous environmental fungus and an opportunistic
pathogen that causes fatal cryptococcal meningitis. Advances in genomics, genetics, and …

Evaluation of Antifungal Activity and Mechanism of Action of Citral against Candida albicans

MCA Leite, APB Bezerra, JP Sousa… - Evidence‐Based …, 2014 - Wiley Online Library
Candida albicans is a yeast that commensally inhabits the human body and can cause
opportunistic or pathogenic infections. Objective. To investigate the antifungal activity of …

Genome-wide analysis of heat stress-stimulated transposon mobility in the human fungal pathogen Cryptococcus deneoformans

A Gusa, V Yadav, C Roth, JD Williams… - Proceedings of the …, 2023 - National Acad Sciences
We recently reported transposon mutagenesis as a significant driver of spontaneous
mutations in the human fungal pathogen Cryptococcus deneoformans during murine …

Overview of selected virulence attributes in Aspergillus fumigatus, Candida albicans, Cryptococcus neoformans, Trichophyton rubrum, and Exophiala dermatitidis

H Boral, B Metin, A Döğen, S Seyedmousavi… - Fungal Genetics and …, 2018 - Elsevier
The incidence of fungal diseases has been increasing since 1980, and is associated with
excessive morbidity and mortality, particularly among immunosuppressed patients. Of the …

Cryptococcus neoformans sexual reproduction is controlled by a quorum sensing peptide

X Tian, GJ He, P Hu, L Chen, C Tao, YL Cui… - Nature …, 2018 - nature.com
Bacterial quorum sensing is a well-characterized communication system that governs a
large variety of collective behaviours. By comparison, quorum sensing regulation in …

Vaccination with a ZNF2oe Strain of Cryptococcus Provides Long-Lasting Protection against Cryptococcosis and Is Effective in Immunocompromised Hosts

T Pham, Y Li, W Watford, X Lin - Infection and Immunity, 2023 - Am Soc Microbiol
Systemic cryptococcosis is fatal without treatment. Even with the current antifungal therapies,
this disease kills 180,000 of 225,000 infected people annually. Exposure to the causative …

Environmental triazole induces cross-resistance to clinical drugs and affects morphophysiology and virulence of Cryptococcus gattii and C. neoformans

RW Bastos, HCS Carneiro, LVN Oliveira… - Antimicrobial agents …, 2018 - Am Soc Microbiol
Cryptococcus gattii and Cryptococcus neoformans are environmental fungi that cause
cryptococcosis, which is usually treated with amphotericin B and fluconazole. However …

[HTML][HTML] Unisexual Reproduction Drives Meiotic Recombination and Phenotypic and Karyotypic Plasticity in Cryptococcus neoformans

S Sun, RB Billmyre, PA Mieczkowski, J Heitman - PLoS Genetics, 2014 - journals.plos.org
In fungi, unisexual reproduction, where sexual development is initiated without the presence
of two compatible mating type alleles, has been observed in several species that can also …

Development of protective inflammation and cell-mediated immunity against Cryptococcus neoformans after exposure to hyphal mutants

B Zhai, KL Wozniak, J Masso-Silva, S Upadhyay… - MBio, 2015 - Am Soc Microbiol
Morphological switch is tightly coupled with the pathogenesis of many dimorphic fungal
pathogens. Cryptococcus neoformans, the major causative agent of cryptococcal meningitis …