Lectins, interconnecting proteins with biotechnological/pharmacological and therapeutic applications
LCBB Coelho, PMS Silva, VLM Lima… - Evidence‐Based …, 2017 - Wiley Online Library
Lectins are proteins extensively used in biomedical applications with property to recognize
carbohydrates through carbohydrate‐binding sites, which identify glycans attached to cell …
carbohydrates through carbohydrate‐binding sites, which identify glycans attached to cell …
Lectins and lectibodies: potential promising antiviral agents
In nature, lectins are widely dispersed proteins that selectively recognize and bind to
carbohydrates and glycoconjugates via reversible bonds at specific binding sites. Many viral …
carbohydrates and glycoconjugates via reversible bonds at specific binding sites. Many viral …
Antiviral lectins: Selective inhibitors of viral entry
CA Mitchell, K Ramessar, BR O'Keefe - Antiviral research, 2017 - Elsevier
Many natural lectins have been reported to have antiviral activity. As some of these have
been put forward as potential development candidates for preventing or treating viral …
been put forward as potential development candidates for preventing or treating viral …
[HTML][HTML] Complement and viral pathogenesis
KA Stoermer, TE Morrison - Virology, 2011 - Elsevier
The complement system functions as an immune surveillance system that rapidly responds
to infection. Activation of the complement system by specific recognition pathways triggers a …
to infection. Activation of the complement system by specific recognition pathways triggers a …
The lantibiotic peptide labyrinthopeptin A1 demonstrates broad anti-HIV and anti-HSV activity with potential for microbicidal applications
Lantibiotics are peptides, produced by bacteria, that contain the noncanonical amino acid
lanthionine and many of them exhibit antibacterial activities. The labyrinthopeptin A1 …
lanthionine and many of them exhibit antibacterial activities. The labyrinthopeptin A1 …
Current status of mannose receptor-targeted drug delivery for improved anti-HIV therapy
In the pursuit of achieving better therapeutic outcomes in the treatment of HIV, innovative
drug delivery strategies have been extensively explored. Mannose receptors, which are …
drug delivery strategies have been extensively explored. Mannose receptors, which are …
Activity of and effect of subcutaneous treatment with the broad-spectrum antiviral lectin griffithsin in two laboratory rodent models
C Barton, JC Kouokam, AB Lasnik… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Griffithsin (GRFT) is a red-alga-derived lectin that binds the terminal mannose residues of N-
linked glycans found on the surface of human immunodeficiency virus type 1 (HIV-1), HIV-2 …
linked glycans found on the surface of human immunodeficiency virus type 1 (HIV-1), HIV-2 …
Lectins as promising therapeutics for the prevention and treatment of HIV and other potential coinfections
M Mazalovska, JC Kouokam - BioMed research international, 2018 - Wiley Online Library
Human immunodeficiency virus‐acquired immunodeficiency syndrome (HIV/AIDS) remains
a global health problem. Current therapeutics specifically target the viral pathogen at various …
a global health problem. Current therapeutics specifically target the viral pathogen at various …
Exploring lectin–glycan interactions to combat COVID-19: Lessons acquired from other enveloped viruses
LC Nascimento da Silva, JSP Mendonça… - …, 2021 - academic.oup.com
The emergence of a new human coronavirus severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has imposed great pressure on the health system worldwide …
coronavirus 2 (SARS-CoV-2) has imposed great pressure on the health system worldwide …
Structure and engineering of tandem repeat lectins
S Notova, F Bonnardel, F Lisacek, A Varrot… - Current opinion in …, 2020 - Elsevier
Highlights•Lectins utilize several strategies for multivalency, resulting in strong avidity for
glycoconjugates.•Tandem repeat lectins can be searched for in the structural database …
glycoconjugates.•Tandem repeat lectins can be searched for in the structural database …