▪ Abstract Tight control of cell-cell communication is essential for the generation of a
normally patterned embryo. A critical mediator of key cell-cell signaling events during …

ABSTRACT β-Catenin can play different roles in the cell, including one as a structural
protein at cell-cell adherens junctions and another as a transcriptional activator mediating …

Wnt-induced formation of nuclear Tcf–β-catenin complexes promotes transcriptional
activation of target genes involved in cell fate decisions. Inappropriate expression of Tcf …

β-Catenin plays a structural role in cell adhesion by binding to cadherins at the intracellular
surface of the plasma membrane and a signaling role in the cytoplasm as the penultimate …

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths
worldwide. β-catenin is widely thought to be a major oncogene in HCC based on the …

Wnt signaling regulates many aspects of development by increasing the signaling activity of
β-catenin. Axin is a negative regulator of the Wnt signaling pathway, and it is responsible for …

The Wingless/Wnt pathway controls cell fates during animal development and regulates
tissue homeostasis as well as stem cell number and differentiation in epithelia. Deregulation …

Wnt signalling controls the transcription of genes that function during normal and malignant
development,. Stimulation by canonical Wnt ligands activates β-catenin (or Drosophila …

The establishment and stability of cell fates during development depend on the integration of
multiple signals, which ultimately modulate specific patterns of gene expression. While there …

β-Catenin and plakoglobin are highly homologous components of cell-cell adherens
junctions linking cadherin receptors to the actin cytoskeleton. β-Catenin, in addition …