The modern epidemic of syphilis

KG Ghanem, S Ram, PA Rice - New England Journal of Medicine, 2020 - Mass Medical Soc
Syphilis Over the past two decades, the incidence of syphilis has increased sharply. The
courses of both untreated and treated disease can be unpredictable. This review presents …

An update on the global epidemiology of syphilis

N Kojima, JD Klausner - Current epidemiology reports, 2018 - Springer
Abstract Purpose of Review Syphilis continues to cause morbidity and mortality worldwide.
While syphilis infection is easily identifiable and treatable, rates of syphilis infection continue …

[HTML][HTML] The wide utility of rabbits as models of human diseases

PJ Esteves, J Abrantes, HM Baldauf… - … & molecular medicine, 2018 - nature.com
Studies using the European rabbit Oryctolagus cuniculus contributed to elucidating
numerous fundamental aspects of antibody structure and diversification mechanisms and …

Virulence and Adhesion of the Treponema pallidum Nichols Strain Simultaneously Decrease in a Continuous-Infection New Zealand White Rabbit Model

J Huang, Y Jiang, W Lin, R Chen, J Zhou… - ACS Infectious …, 2023 - ACS Publications
Syphilis is a sexually transmitted disease caused by T. pallidum, and the T. pallidum Nichols
strain is widely used with the New Zealand white rabbit model for evaluating drug and …

[HTML][HTML] The intersection of HIV and syphilis: update on the key considerations in testing and management

M Ren, T Dashwood, S Walmsley - Current HIV/AIDS Reports, 2021 - Springer
Abstract Purpose of Review To highlight recent trends in the epidemiology of HIV and
syphilis, the impact of the COVID epidemic, our approach to care of co-infected patients, and …

Syphilis in pregnancy

EH Adhikari - Obstetrics & Gynecology, 2020 - journals.lww.com
Syphilis in Pregnancy : Obstetrics & Gynecology Syphilis in Pregnancy : Obstetrics &
Gynecology ACOG.org ACOG Clinical Green Journal For Patients Store Log in or Register …

[HTML][HTML] Deep proteome coverage advances knowledge of Treponema pallidum protein expression profiles during infection

S Houston, A Gomez, A Geppert, A Eshghi, DS Smith… - Scientific Reports, 2023 - nature.com
Comprehensive proteome-wide analysis of the syphilis spirochete, Treponema pallidum
ssp. pallidum, is technically challenging due to high sample complexity, difficulties with …

The Treponema pallidum Outer Membrane

JD Radolf, S Kumar - Spirochete Biology: The Post Genomic Era, 2018 - Springer
The outer membrane (OM) of Treponema pallidum, the uncultivatable agent of venereal
syphilis, has long been the subject of misconceptions and controversy. Decades ago …

PCR detection for syphilis diagnosis: Status and prospects

C Zhou, X Zhang, W Zhang, J Duan… - Journal of clinical …, 2019 - Wiley Online Library
Syphilis, a re‐emerging public health problem worldwide caused by Treponema pallidum
subsp pallidum (T. pallidum), usually induces systemic and chronic inflammation in hosts …

[HTML][HTML] Immunization with a tri-antigen syphilis vaccine significantly attenuates chancre development, reduces bacterial load, and inhibits dissemination of …

SA Lukehart, B Molini, A Gomez, C Godornes, R Hof… - Vaccine, 2022 - Elsevier
Syphilis continues to be a significant public health concern worldwide. The disease is
endemic in many low-and middle-income countries, and rates have risen sharply in high …