Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous
compounds, including lipid esters. Physiological functions of carboxylesterases in lipid …

A fine-tuned balance between cholesterol uptake and excretion by the body is pivotal to
maintain health and to remain free from the deleterious consequences of cholesterol …

Digested dietary fats are taken up by enterocytes where they are assembled into pre-
chylomicrons in the endoplasmic reticulum followed by transport to the Golgi for maturation …

Nonalcoholic fatty liver disease (NAFLD) is one of the major health concerns worldwide.
Farnesoid X receptor (FXR) is considered a therapeutic target for treatment of NAFLD …

Background & Aims Enteroendocrine cells (EECs) and their hormones are essential
regulators of whole-body energy homeostasis. EECs sense luminal nutrients and microbial …

Dietary lipid absorption and lipoprotein secretion by the gut are important in maintaining
whole-body energy homeostasis and have significant implications for health and disease …

Extracellular vesicles (EVs) such as exosomes are secretory vesicles that act as autocrine,
paracrine, or endocrine messengers; mediate intercellular cross-talk; and carry a cargo of …

Mammalian carboxylesterases (CESs) are essential members of serine esterase hydrolase
superfamily, which are widely distributed in many tissues including liver, intestine, lung and …

Diet-induced obesity mouse models are widely utilized to investigate the underlying
mechanisms of dyslipidemia, glucose intolerance, insulin resistance, hepatic steatosis, and …

As circulating lipid levels are balanced by the rate of lipoprotein release and clearance from
the plasma, lipid absorption in the small intestine critically contributes to the maintenance of …