In addition to proliferating cancer cells and various types of normal cells, such as those of
the bone marrow, conventional cytotoxic chemotherapeutics affect the endothelium of the …

The administration of chemotherapy at reduced doses given at regular, frequent time
intervals, termed 'metronomic'chemotherapy, presents an alternative to standard maximal …

Purpose Vascular endothelial growth factor (VEGF) plays an important role in the biology of
ovarian cancer (OC). Inhibitors of VEGF suppress tumor growth in OC models. Metronomic …

Recent preclinical studies have shown that frequent administration in vivo of low doses of
chemotherapeutic drugs (“metronomic” dosing) can affect tumor endothelium and inhibit …

It is not uncommon for new anti-cancer drugs or therapies to show highly effective, and
sometimes even spectacular anti-cancer treatment results using transplantable tumors in …

With more than half a million new cases each year, hepatocellular carcinoma (HCC) is the
fifth most common tumor worldwide and the third cause of cancer-related deaths [1]. At the …

A number of recent preclinical studies have sparked interest in the conceptof exploiting
conventional chemotherapeutic drugs as antiangiogenics. Such antiangiogenic activity is …

Integrin α5β1 is expressed on activated endothelial cells and plays a critical role in tumor
angiogenesis. We hypothesized that a novel integrin α5β1 antagonist, ATN‐161, would …

Purpose We performed a phase II study to evaluate the combination of imatinib mesylate, an
adenosine triphosphate mimetic, tyrosine kinase inhibitor, plus hydroxyurea, a …

Gambogic acid (GA), the main active compound of Gamboge hanburyi, has been previously
reported to activate apoptosis in many types of cancer cell lines by targeting transferrin …