Genetic and epigenetic etiology underlying autism spectrum disorder

SH Yoon, J Choi, WJ Lee, JT Do - Journal of clinical medicine, 2020 - mdpi.com
Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder characterized
by difficulties in social interaction, language development delays, repeated body …

The involvement of Reelin in neurodevelopmental disorders

TD Folsom, SH Fatemi - Neuropharmacology, 2013 - Elsevier
Reelin is a glycoprotein that serves important roles both during development (regulation of
neuronal migration and brain lamination) and in adulthood (maintenance of synaptic …

Extracellular matrix abnormalities in schizophrenia

S Berretta - Neuropharmacology, 2012 - Elsevier
Emerging evidence points to the involvement of the brain extracellular matrix (ECM) in the
pathophysiology of schizophrenia (SZ). Abnormalities affecting several ECM components …

Neural ECM molecules in synaptic plasticity, learning, and memory

O Senkov, P Andjus, L Radenovic, E Soriano… - Progress in brain …, 2014 - Elsevier
Neural extracellular matrix (ECM) molecules derived from neurons and glial cells
accumulate in the extracellular space and regulate synaptic plasticity through modulation of …

Overexpression of Reelin prevents the manifestation of behavioral phenotypes related to schizophrenia and bipolar disorder

CM Teixeira, ED Martín, I Sahún, N Masachs… - …, 2011 - nature.com
Despite the impact of schizophrenia and mood disorders, which in extreme cases can lead
to death, recent decades have brought little progress in the development of new treatments …

Mouse models of genetic effects on cognition: relevance to schizophrenia

F Papaleo, BK Lipska, DR Weinberger - Neuropharmacology, 2012 - Elsevier
Cognitive dysfunction is a core feature of schizophrenia. Growing evidence indicates that a
wide variety of genetic mutations and polymorphisms impact cognition and may thus be …

The Genetic Variation of RELN Expression in Schizophrenia and Bipolar Disorder

G Ovadia, S Shifman - PloS one, 2011 - journals.plos.org
Reelin plays an important role in the development and function of the brain and has been
linked to different neuropsychiatric diseases. To further clarify the connection between reelin …

Genetic studies of schizophrenia: an update

J Chen, F Cao, L Liu, L Wang, X Chen - Neuroscience bulletin, 2015 - Springer
Schizophrenia (SCZ) is a complex and heterogeneous mental disorder that affects about 1%
of global population. In recent years, considerable progress has been made in genetic …

Meta-analyses of RELN variants in neuropsychiatric disorders

N Chen, Y Bao, Y Xue, Y Sun, D Hu, S Meng… - Behavioural brain …, 2017 - Elsevier
Reelin is a critical extracellular matrix glycoprotein and implicated in neurodevelopment and
psychiatric disorders in animal model studies. The genetic polymorphism of RELN has also …

Dorsal forebrain-specific deficiency of Reelin-Dab1 signal causes behavioral abnormalities related to psychiatric disorders

H Imai, H Shoji, M Ogata, Y Kagawa, Y Owada… - Cerebral …, 2017 - academic.oup.com
Reelin-Dab1 signaling is involved in brain development and neuronal functions. The
abnormalities in the signaling through either reduction of Reelin and Dab1 gene …