Genetic and epigenetic etiology underlying autism spectrum disorder
Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder characterized
by difficulties in social interaction, language development delays, repeated body …
by difficulties in social interaction, language development delays, repeated body …
The involvement of Reelin in neurodevelopmental disorders
TD Folsom, SH Fatemi - Neuropharmacology, 2013 - Elsevier
Reelin is a glycoprotein that serves important roles both during development (regulation of
neuronal migration and brain lamination) and in adulthood (maintenance of synaptic …
neuronal migration and brain lamination) and in adulthood (maintenance of synaptic …
Extracellular matrix abnormalities in schizophrenia
S Berretta - Neuropharmacology, 2012 - Elsevier
Emerging evidence points to the involvement of the brain extracellular matrix (ECM) in the
pathophysiology of schizophrenia (SZ). Abnormalities affecting several ECM components …
pathophysiology of schizophrenia (SZ). Abnormalities affecting several ECM components …
Neural ECM molecules in synaptic plasticity, learning, and memory
Neural extracellular matrix (ECM) molecules derived from neurons and glial cells
accumulate in the extracellular space and regulate synaptic plasticity through modulation of …
accumulate in the extracellular space and regulate synaptic plasticity through modulation of …
Overexpression of Reelin prevents the manifestation of behavioral phenotypes related to schizophrenia and bipolar disorder
CM Teixeira, ED Martín, I Sahún, N Masachs… - …, 2011 - nature.com
Despite the impact of schizophrenia and mood disorders, which in extreme cases can lead
to death, recent decades have brought little progress in the development of new treatments …
to death, recent decades have brought little progress in the development of new treatments …
Mouse models of genetic effects on cognition: relevance to schizophrenia
F Papaleo, BK Lipska, DR Weinberger - Neuropharmacology, 2012 - Elsevier
Cognitive dysfunction is a core feature of schizophrenia. Growing evidence indicates that a
wide variety of genetic mutations and polymorphisms impact cognition and may thus be …
wide variety of genetic mutations and polymorphisms impact cognition and may thus be …
The Genetic Variation of RELN Expression in Schizophrenia and Bipolar Disorder
G Ovadia, S Shifman - PloS one, 2011 - journals.plos.org
Reelin plays an important role in the development and function of the brain and has been
linked to different neuropsychiatric diseases. To further clarify the connection between reelin …
linked to different neuropsychiatric diseases. To further clarify the connection between reelin …
Genetic studies of schizophrenia: an update
Schizophrenia (SCZ) is a complex and heterogeneous mental disorder that affects about 1%
of global population. In recent years, considerable progress has been made in genetic …
of global population. In recent years, considerable progress has been made in genetic …
Meta-analyses of RELN variants in neuropsychiatric disorders
Reelin is a critical extracellular matrix glycoprotein and implicated in neurodevelopment and
psychiatric disorders in animal model studies. The genetic polymorphism of RELN has also …
psychiatric disorders in animal model studies. The genetic polymorphism of RELN has also …
Dorsal forebrain-specific deficiency of Reelin-Dab1 signal causes behavioral abnormalities related to psychiatric disorders
Reelin-Dab1 signaling is involved in brain development and neuronal functions. The
abnormalities in the signaling through either reduction of Reelin and Dab1 gene …
abnormalities in the signaling through either reduction of Reelin and Dab1 gene …