Transposable elements are abundant in the human genome, and great strides have been
made in pinpointing variations in these repetitive sequences using whole-genome …

Transposable elements give rise to interspersed repeats, sequences that comprise most of
our genomes. These mobile DNAs have been historically underappreciated—both because …

About half of all cancers have somatic integrations of retrotransposons. Here, to characterize
their role in oncogenesis, we analyzed the patterns and mechanisms of somatic …

Structural variants are implicated in numerous diseases and make up the majority of varying
nucleotides among human genomes. Here we describe an integrated set of eight structural …

Motivation Structural variants are defined as genomic variants larger than 50 bp. They have
been shown to affect more bases in any given genome than single-nucleotide …

Mobile element insertions (MEIs) represent∼ 25% of all structural variants in human
genomes. Moreover, when they disrupt genes, MEIs can influence human traits and …

The human genome is arguably the most complete mammalian reference assembly,,, yet
more than 160 euchromatic gaps remain,, and aspects of its structural variation remain …

The growing knowledge about the influence of transposable elements (TE s) on (a) long‐
term genome and transcriptome evolution;(b) genomic, transcriptomic and epigenetic …

In an effort to more fully understand the full spectrum of human genetic variation, we
generated deep single-molecule, real-time (SMRT) sequencing data from two haploid …

Personalized medicine is expected to benefit from combining genomic information with
regular monitoring of physiological states by multiple high-throughput methods. Here, we …