The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

A brain organoid is a self-organizing three-dimensional tissue derived from human
embryonic stem cells or pluripotent stem cells and is able to simulate the architecture and …

To position the mitotic spindle within the cell, dynamic plus ends of astral microtubules are
pulled by membrane-associated cortical force-generating machinery. However, in contrast to …

Microtubules are cytoskeletal filaments essential for numerous aspects of cell physiology.
They are polarized polymeric tubes with a fast growing plus end and a slow growing minus …

As microtubule-organizing centers of animal cells, centrosomes guide the formation of the
bipolar spindle that segregates chromosomes during mitosis. At mitosis onset, centrosomes …

Microtubule organization has a crucial role in regulating cell architecture. The geometry of
microtubule arrays strongly depends on the distribution of sites responsible for microtubule …

Primary microcephaly (MCPH) is an autosomal recessive sporadic neurodevelopmental
ailment with a trivial head size characteristic that is below 3–4 standard deviations. MCPH is …

Primary microcephaly (MCPH), is a neurological disorder characterized by small brain size
that results in numerous developmental problems, including intellectual disability, motor and …

The pericentriolar material (PCM) that accumulates around the centriole expands during
mitosis and nucleates microtubules. Here, we show the cooperative roles of the centriole …

Micronuclei resulting from improper chromosome segregation foster chromosome
rearrangements. 1, 2 To prevent micronuclei formation in mitosis, the dynamic plus ends of …