Chronic wounds are characterized by their inability to heal within an expected time frame
and have emerged as an increasingly important clinical problem over the past several …

Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …

Diabetic wound (DW) therapy is currently a big challenge in medicine and strategies to
enhance neurogenesis and angiogenesis have appeared to be a promising direction …

Skin wounds greatly affect the global healthcare system, creating a substantial burden on
the economy and society. Moreover, the situation is exacerbated by low healing rates, which …

Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …

The lung is a primary organ for gas exchange in mammals that represents the largest
epithelial surface in direct contact with the external environment. It also serves as a crucial …

Macrophages are key immune cells that respond to infections, and modulate
pathophysiological conditions such as wound healing. By possessing phagocytic activities …

Macrophage immunotherapy is an emerging treatment strategy that modulates the immune
system to promote wound healing. The functionality and regeneration of tissue depend on …

Chronic inflammation is one of the hallmarks of chronic wounds and is tightly coupled to
immune regulation. The dysregulation of the immune system leads to continuing …

The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …