Human neurological disorders such as Parkinson's disease, Huntington's disease,
amyotrophic lateral sclerosis (ALS), Alzheimer's disease, multiple sclerosis (MS), stroke, and …

There is increasing evidence that mesenchymal stem cells (MSCs) have the ability to
migrate and engraft into tumor sites and exert stimulatory effects on cancer cell growth …

Refractory focal epilepsy is a devastating disease for which there is frequently no effective
treatment. Gene therapy represents a promising alternative, but treating epilepsy in this way …

PURPOSE: Ionizing radiation, an important component of glioma therapy, is critically
dependent on tumor oxygenation. However, gliomas are notable for areas of necrosis and …

Niemann–Pick type C disease (NP-C) is a fatal neurodegenerative lysosomal storage
disorder. It is caused in 95% of cases by a mutation in the NPC1 gene that encodes NPC1 …

Despite advances in diagnostic imaging and drug discovery, primary malignant brain tumors
remain fatal. Median survival for patients with the most severe forms is rarely past eight …

During the past decade, in vivo administration of viral gene transfer vectors for treatment of
numerous human diseases has been brought from bench to bedside in the form of clinical …

Niemann–Pick disease type C1 (NP-C) is a prematurely lethal genetic lysosomal storage
disorder with neurological and visceral pathology resulting from mutations in the NPC1 gene …

In addition to stem cells providing a better understanding about the biology and origins of
gliomas, new therapeutic approaches have been developed based on the use of stem cells …

Advances in gene-based medicine since 1990s have ushered in new therapeutic strategy of
gene therapy for inborn error genetic diseases and cancer. Malignant brain tumors such as …