Langmuir monolayers at the air/water interface have been used for decades to mimic cell
membranes in attempts to determine the mechanisms behind the physiological action of …

Lipidomics and proteomics have undergone a tremendous revolution, and the knowledge
about drugs' mechanism of action in biological membranes has been deepened. Methods to …

Molecules able to prevent lipid peroxidation have attracted attention due to their potential to
act against lipid peroxidation-induced disorders including cancer and neurological …

Temozolomide (TMZ) is the first-line treatment for Glioblastoma Multiforme (GBM). After
administration, TMZ is rapidly converted into its active metabolite (MTIC). However, its …

While the majority of known antimicrobial peptides are cationic, a small number consist of
short Asp-rich sequences that are anionic. These require metal ions to become biologically …

The molecular-level interaction of levofloxacin with lung surfactant was investigated using
Langmuir monolayers and atomistic molecular dynamics (MD) simulations. In the simulation …

Natural compounds such as caffeine (CA), gallic acid (GA) and tannic acid (TA) have been
reported to be useful for Alzheimer's disease (AD) therapy. It was proved that some natural …

Cyclosporin A (CsA), a hydrophobic peptide, mainly known for its immunosuppressant
properties, has shown a broad range of biological activities, including antimalarial action …

Understanding the interaction between pulmonary surfactant (PS) and inhalable pollutants
is vital for risk assessment of respiratory health. Here, PS extracted from porcine lung (EPS) …

Lipophilicity is a physicochemical property of crucial importance in drug discovery and drug
design. Biomimetic models, such as liposomes and micelles, constitute a valuable tool for …