Calcium phosphate is the inorganic mineral of hard tissues such as bone and teeth. Due to
their similarities to the natural bone, calcium phosphates are highly biocompatible and …

Small interfering RNA (siRNA) is a relatively novel nucleic acid-based therapy to treat
diseases such as cancer. Nevertheless, substantial obstacles to its clinical applications have …

Stem cells are capable of long-term self-renewal and differentiation into specialised cell
types, making them an ideal candidate for a cell source for regenerative medicine. The …

Traditional transfection agents including cationic lipids and polymers have high efficiency
but cause cytotoxicity. While cell penetrating peptide based transfection agents exhibit …

Directing stem cell fate remains a major area of interest and also a hurdle to many,
particularly in the field of regenerative medicine. Unfortunately, conventional methods of …

SiRNA-based strategies appear to be an exciting new approach for the treatment of
respiratory diseases. To extrapolate siRNA-mediated interventions from bench to bedside in …

The transcription factor NF-κB and its signaling cascade both play key roles in all
inflammatory processes. The most critical member of the NF-κB transcription factor family is …

Recently, survivin has been attracting great attention because it plays an important role in
inhibiting the apoptosis process of tumor cells. Down-regulating the expression of survivin …

To elucidate the effect of binding affinity for siRNA on the in vivo antitumor efficacy of
polyplexes, five kinds of galactose modified trimethyl chitosan-cysteine (GTC) conjugate …

siRNA delivery targeting tumor cells and cancer-associated immune cells has been gaining
momentum in the last few years. A combinatorial approach for silencing crucial factors …