The current landscape of NKT cell immunotherapy and the hills ahead

A Nelson, JD Lukacs, B Johnston - Cancers, 2021 - mdpi.com
Simple Summary Natural killer T (NKT) cells are a subset of lipid-reactive T cells that
enhance anti-tumor immunity. While preclinical studies have shown NKT cell …

Poly (lactic acid)-based particulate systems are promising tools for immune modulation

C Peres, AI Matos, J Conniot, V Sainz, E Zupančič… - Acta biomaterialia, 2017 - Elsevier
Abstract Poly (lactic acid)(PLA) is one of the most successful and versatile polymers
explored for controlled delivery of bioactive molecules. Its attractive properties of …

NKT cell networks in the regulation of tumor immunity

FC Robertson, JA Berzofsky, M Terabe - Frontiers in immunology, 2014 - frontiersin.org
CD1d-restricted natural killer T (NKT) cells lie at the interface between the innate and
adaptive immune systems and are important mediators of immune responses and tumor …

Nanoparticle mediated cancer immunotherapy

J Gupta, HA Safdari, M Hoque - Seminars in Cancer Biology, 2021 - Elsevier
The versatility and nanoscale size have helped nanoparticles (NPs) improve the efficacy of
conventional cancer immunotherapy and opened up exciting approaches to combat cancer …

Synergistic induction of adaptive antitumor immunity by codelivery of antigen with α-galactosylceramide on exosomes

U Gehrmann, S Hiltbrunner, AM Georgoudaki… - Cancer research, 2013 - AACR
Exosomes and the invariant NKT (iNKT) immune cell ligand α-galactosylceramide (αGC)
may offer novel tools for cancer immunotherapy. In this study, we investigated whether …

Application of nanotechnologies for improved immune response against infectious diseases in the developing world

M Look, A Bandyopadhyay, JS Blum… - Advanced drug delivery …, 2010 - Elsevier
There is an urgent need for new strategies to combat infectious diseases in developing
countries. Many pathogens have evolved to elude immunity and this has limited the utility of …

cGAMP-adjuvanted multivalent influenza mRNA vaccines induce broadly protective immunity through cutaneous vaccination in mice

W Zhu, L Wei, C Dong, Y Wang, J Kim, Y Ma… - … Therapy-Nucleic Acids, 2022 - cell.com
Increasing preclinical and clinical results have demonstrated that mRNA vaccines efficiently
prevent infectious diseases and are safe in animal models and humans. In this study, we …

Nanotechnology-based manipulation of dendritic cells for enhanced immunotherapy strategies

R Klippstein, D Pozo - Nanomedicine: Nanotechnology, Biology and …, 2010 - Elsevier
Dendritic cells (DCs) are potent antigen-presenting cells capable of initiating a primary
immune response and possess the ability to activate T cells and stimulate the growth and …

Robust IgG responses to nanograms of antigen using a biomimetic lipid-coated particle vaccine

A Bershteyn, MC Hanson, MP Crespo, JJ Moon… - Journal of controlled …, 2012 - Elsevier
New subunit vaccine formulations with increased potency are of interest to improve immune
responses against poorly immunogenic antigens, to avoid vaccine shortages in pandemic …

[HTML][HTML] Selection of adjuvants for enhanced vaccine potency

W Wang, M Singh - World Journal of Vaccines, 2011 - scirp.org
The advent of mass vaccination has saved millions of human lives and revolutionized the
quality of life. Vaccination is currently one of the most cost effective ways of managing …