Subcutaneous administration of a monoclonal antibody to prevent malaria
K Kayentao, A Ongoiba, AC Preston… - … England Journal of …, 2024 - Mass Medical Soc
Background Subcutaneous administration of the monoclonal antibody L9LS protected adults
against controlled Plasmodium falciparum infection in a phase 1 trial. Whether a monoclonal …
against controlled Plasmodium falciparum infection in a phase 1 trial. Whether a monoclonal …
Vaccines and monoclonal antibodies: new tools for malaria control
K Miura, Y Flores-Garcia, CA Long… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Malaria remains one of the biggest health problems in the world. While significant reductions
in malaria morbidity and mortality had been achieved from 2000 to 2015, the favorable trend …
in malaria morbidity and mortality had been achieved from 2000 to 2015, the favorable trend …
The emergence of artemisinin partial resistance in Africa: how do we respond?
PJ Rosenthal, V Asua, JA Bailey… - The Lancet Infectious …, 2024 - thelancet.com
Malaria remains one of the most important infectious diseases in the world, with the greatest
burden in sub-Saharan Africa, primarily from Plasmodium falciparum infection. The …
burden in sub-Saharan Africa, primarily from Plasmodium falciparum infection. The …
[HTML][HTML] The public health impact and cost-effectiveness of the R21/Matrix-M malaria vaccine: a mathematical modelling study
N Schmit, HM Topazian, HM Natama… - The Lancet Infectious …, 2024 - thelancet.com
Summary Background The R21/Matrix-M vaccine has demonstrated high efficacy against
Plasmodium falciparum clinical malaria in children in sub-Saharan Africa. Using trial data …
Plasmodium falciparum clinical malaria in children in sub-Saharan Africa. Using trial data …
[HTML][HTML] Blood-stage malaria vaccine candidate RH5. 1/Matrix-M in healthy Tanzanian adults and children; an open-label, non-randomised, first-in-human, single …
SE Silk, WF Kalinga, J Salkeld, IM Mtaka… - The Lancet Infectious …, 2024 - thelancet.com
Background A blood-stage Plasmodium falciparum malaria vaccine would provide a second
line of defence to complement partially effective or waning immunity conferred by the …
line of defence to complement partially effective or waning immunity conferred by the …
[HTML][HTML] Malaria vaccination: hurdles to reach high-risk children
F Amimo - BMC medicine, 2024 - Springer
Ensuring that malaria vaccines deliver maximum public health impact is non-trivial. Drawing
on current research, this article examines hurdles that malaria immunization may face to …
on current research, this article examines hurdles that malaria immunization may face to …
Malaria vaccines: a new era of prevention and control
Malaria killed over 600,000 people in 2022, a death toll that has not improved since 2015.
Additionally, parasites and mosquitoes resistant to existing interventions are spreading …
Additionally, parasites and mosquitoes resistant to existing interventions are spreading …
The impact of Plasmodium-driven immunoregulatory networks on immunity to malaria
Malaria, caused by infection with Plasmodium parasites, drives multiple regulatory
responses across the immune landscape. These regulatory responses help to protect …
responses across the immune landscape. These regulatory responses help to protect …
[HTML][HTML] Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype
JR Barrett, D Pipini, ND Wright, AJR Cooper, G Gorini… - Cell, 2024 - cell.com
The highly conserved and essential Plasmodium falciparum reticulocyte-binding protein
homolog 5 (PfRH5) has emerged as the leading target for vaccines against the disease …
homolog 5 (PfRH5) has emerged as the leading target for vaccines against the disease …
Empfehlungen der Ständigen Impfkommission (STIKO) und der Deutschen Gesellschaft für Tropenmedizin, Reisemedizin und Globale Gesundheit eV (DTG) zu …
Die STIKO empfiehlt Reiseimpfungen zum individuellen Schutz Reisender mit einem
Expositionsrisiko gegenüber bestimmten impfpräventablen Erkrankungen und um den …
Expositionsrisiko gegenüber bestimmten impfpräventablen Erkrankungen und um den …