Fungal secondary metabolism: regulation, function and drug discovery
NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …
[PDF][PDF] Fungi as mediators linking organisms and ecosystems
M Bahram, T Netherway - FEMS Microbiology Reviews, 2022 - academic.oup.com
Fungi form a major and diverse component of most ecosystems on Earth. They are both
micro and macroorganisms with high and varying functional diversity as well as great …
micro and macroorganisms with high and varying functional diversity as well as great …
[HTML][HTML] Genome mining of biosynthetic and chemotherapeutic gene clusters in Streptomyces bacteria
Streptomyces bacteria are known for their prolific production of secondary metabolites, many
of which have been widely used in human medicine, agriculture and animal health. To guide …
of which have been widely used in human medicine, agriculture and animal health. To guide …
Aspergillus flavus
S Amaike, NP Keller - Annual review of phytopathology, 2011 - annualreviews.org
Aspergillus flavus is saprophytic soil fungus that infects and contaminates preharvest and
postharvest seed crops with the carcinogenic secondary metabolite aflatoxin. The fungus is …
postharvest seed crops with the carcinogenic secondary metabolite aflatoxin. The fungus is …
The birth, evolution and death of metabolic gene clusters in fungi
Fungi contain a remarkable diversity of both primary and secondary metabolic pathways
involved in ecologically specialized or accessory functions. Genes in these pathways are …
involved in ecologically specialized or accessory functions. Genes in these pathways are …
[HTML][HTML] Drivers of genetic diversity in secondary metabolic gene clusters within a fungal species
Filamentous fungi produce a diverse array of secondary metabolites (SMs) critical for
defense, virulence, and communication. The metabolic pathways that produce SMs are …
defense, virulence, and communication. The metabolic pathways that produce SMs are …
Metabolic gene clusters in eukaryotes
HW Nützmann, C Scazzocchio… - Annual Review of …, 2018 - annualreviews.org
In bacteria, more than half of the genes in the genome are organized in operons. In contrast,
in eukaryotes, functionally related genes are usually dispersed across the genome. There …
in eukaryotes, functionally related genes are usually dispersed across the genome. There …
[HTML][HTML] The Genome of Nectria haematococca: Contribution of Supernumerary Chromosomes to Gene Expansion
JJ Coleman, SD Rounsley, M Rodriguez-Carres… - PLoS …, 2009 - journals.plos.org
The ascomycetous fungus Nectria haematococca,(asexual name Fusarium solani), is a
member of a group of> 50 species known as the “Fusarium solani species complex” …
member of a group of> 50 species known as the “Fusarium solani species complex” …
Secondary metabolic gene clusters: evolutionary toolkits for chemical innovation
A Osbourn - Trends in genetics, 2010 - cell.com
Microbes and plants produce a huge array of secondary metabolites that have important
ecological functions. These molecules have long been exploited in medicine as antibiotics …
ecological functions. These molecules have long been exploited in medicine as antibiotics …
Horizontal gene transfer in fungi
DA Fitzpatrick - FEMS microbiology letters, 2012 - academic.oup.com
Horizontal gene transfer (HGT) is frequently observed in prokaryotes and until recently was
assumed to be of limited importance to eukaryotes. However, there is an increasing body of …
assumed to be of limited importance to eukaryotes. However, there is an increasing body of …