Fungal secondary metabolism: regulation, function and drug discovery

NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …

[PDF][PDF] Fungi as mediators linking organisms and ecosystems

M Bahram, T Netherway - FEMS Microbiology Reviews, 2022 - academic.oup.com
Fungi form a major and diverse component of most ecosystems on Earth. They are both
micro and macroorganisms with high and varying functional diversity as well as great …

[HTML][HTML] Genome mining of biosynthetic and chemotherapeutic gene clusters in Streptomyces bacteria

KC Belknap, CJ Park, BM Barth, CP Andam - Scientific Reports, 2020 - nature.com
Streptomyces bacteria are known for their prolific production of secondary metabolites, many
of which have been widely used in human medicine, agriculture and animal health. To guide …

Aspergillus flavus

S Amaike, NP Keller - Annual review of phytopathology, 2011 - annualreviews.org
Aspergillus flavus is saprophytic soil fungus that infects and contaminates preharvest and
postharvest seed crops with the carcinogenic secondary metabolite aflatoxin. The fungus is …

The birth, evolution and death of metabolic gene clusters in fungi

A Rokas, JH Wisecaver, AL Lind - Nature Reviews Microbiology, 2018 - nature.com
Fungi contain a remarkable diversity of both primary and secondary metabolic pathways
involved in ecologically specialized or accessory functions. Genes in these pathways are …

[HTML][HTML] Drivers of genetic diversity in secondary metabolic gene clusters within a fungal species

AL Lind, JH Wisecaver, C Lameiras, P Wiemann… - PLoS …, 2017 - journals.plos.org
Filamentous fungi produce a diverse array of secondary metabolites (SMs) critical for
defense, virulence, and communication. The metabolic pathways that produce SMs are …

Metabolic gene clusters in eukaryotes

HW Nützmann, C Scazzocchio… - Annual Review of …, 2018 - annualreviews.org
In bacteria, more than half of the genes in the genome are organized in operons. In contrast,
in eukaryotes, functionally related genes are usually dispersed across the genome. There …

[HTML][HTML] The Genome of Nectria haematococca: Contribution of Supernumerary Chromosomes to Gene Expansion

JJ Coleman, SD Rounsley, M Rodriguez-Carres… - PLoS …, 2009 - journals.plos.org
The ascomycetous fungus Nectria haematococca,(asexual name Fusarium solani), is a
member of a group of> 50 species known as the “Fusarium solani species complex” …

Secondary metabolic gene clusters: evolutionary toolkits for chemical innovation

A Osbourn - Trends in genetics, 2010 - cell.com
Microbes and plants produce a huge array of secondary metabolites that have important
ecological functions. These molecules have long been exploited in medicine as antibiotics …

Horizontal gene transfer in fungi

DA Fitzpatrick - FEMS microbiology letters, 2012 - academic.oup.com
Horizontal gene transfer (HGT) is frequently observed in prokaryotes and until recently was
assumed to be of limited importance to eukaryotes. However, there is an increasing body of …