It was once widely held that nearly all reactions in biology were catalyzed via mechanisms
involving paired electron species. Beginning approximately 40 years ago, this paradigm was …

Radical S-adenosyl-l-methionine (SAM) enzymes belong to a family of catalysts whose
number of annotated sequences is still growing. Upon the one-electron reduction of a …

S-Adenosylmethionine (SAM, also known as AdoMet) radical enzymes use SAM and a [4Fe-
4S] cluster to catalyze a diverse array of reactions. They adopt a partial triose-phosphate …

Abstract d-Amino acid residues, found in countless peptides and natural products including
ribosomally synthesized and post-translationally modified peptides (RiPPs), are critical for …

Covering: up to the end of 2017 C–C bond formations are frequently the key steps in
cofactor and natural product biosynthesis. Historically, C–C bond formations were thought to …

A vast number of enzymes are now known to belong to a superfamily known as radical SAM,
which all contain a [4Fe–4S] cluster ligated by three cysteine residues. The remaining …

Arylsulfatases require a maturating enzyme to perform a co-or posttranslational modification
to form a catalytically essential formylglycine (FGly) residue. In organisms that live …

An explosion of remarkable chemical transformations has been witnessed in the past
decade as a result of the radical S-adenosyl-l-methionine (SAM)(RS) superfamily of …

The 2-deoxy-scyllo-inosamine (DOIA) dehydrogenases are key enzymes in the biosynthesis
of 2-deoxystreptamine–containing aminoglycoside antibiotics. In contrast to most DOIA …

Radical SAM (RS) enzymes use a 5′-deoxyadenosyl 5′-radical generated from a
reductive cleavage of S-adenosyl-l-methionine to catalyze over 40 distinct reaction types. A …