Endometriosis is a common condition associated with infertility that causes chronic pain in
many, but not all, women. It is defined by the presence of endometrial-like tissue outside the …

Introduction: Pharmacotherapy has a pivotal role in the management of endometriosis with
long-term treatments balancing clinical efficacy (control of pain symptoms and prevention of …

Peripheral tissue metabolism of steroids (intracrinology) is now accepted as a key way in
which tissues, such as the endometrium, can utilise inactive steroids present in the blood to …

Steroid sulphatase (STS), involved in the hydrolysis of steroid sulphates, plays an important
role in the formation of both active oestrogens and androgens. Since these steroids …

Introduction: Endometriosis is a chronic benign estrogen-dependent disease characterized
by the presence of endometriotic glands and stroma outside the uterine cavity. Although …

Steroid sulphatase is an emerging drug target for the endocrine therapy of hormone-
dependent diseases, catalysing oestrogen sulphate hydrolysis to oestrogen. Drug discovery …

Introduction: Steroid sulfatase (STS) enzyme is responsible for transforming the inactive
sulfate metabolites of steroid sex hormones into the active free steroids. Both the deficiency …

During the past 25 years, the modulation of estrogen action by inhibition of 17β-
hydroxysteroid dehydrogenase types 1 and 2 (17β-HSD1 and 17β-HSD2), respectively, has …

In the present article, we reviewed the sulfamate-containing compounds reported as
bioactive molecules. The possible molecular targets of sulfamate derivatives include steroid …

The purpose of this review article is to provide an overview of recent achievements in the
synthesis of novel steroid sulphatase (STS) inhibitors. STS is a crucial enzyme in the …