BCG-induced protection: effects on innate immune memory

MG Netea, R van Crevel - Seminars in immunology, 2014 - Elsevier
Abstract The Bacille Calmette–Guerin (BCG) vaccine is the only vaccine proved to be
effective against tuberculosis and it remains the most commonly used vaccine worldwide. In …

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

J Kleinnijenhuis, J Quintin, F Preijers… - Proceedings of the …, 2012 - National Acad Sciences
Adaptive features of innate immunity, recently described as “trained immunity,” have been
documented in plants, invertebrate animals, and mice, but not yet in humans. Here we show …

Long-lasting effects of BCG vaccination on both heterologous Th1/Th17 responses and innate trained immunity

J Kleinnijenhuis, J Quintin, F Preijers, CS Benn… - Journal of innate …, 2014 - karger.com
We have recently shown that BCG (Bacillus Calmette-Guérin) vaccination in healthy
volunteers induces epigenetic reprogramming of monocytes, leading to increased cytokine …

Fiction and facts about BCG imparting trained immunity against COVID-19

G Kaur, S Singh, S Nanda, MA Zafar, JA Malik… - Vaccines, 2022 - mdpi.com
The Bacille Calmette-Guérin or BCG vaccine, the only vaccine available against
Mycobacterium tuberculosis can induce a marked Th1 polarization of T-cells, characterized …

Autophagy controls BCG-induced trained immunity and the response to intravesical BCG therapy for bladder cancer

K Buffen, M Oosting, J Quintin, A Ng… - PLoS …, 2014 - journals.plos.org
The anti-tuberculosis-vaccine Bacillus Calmette-Guérin (BCG) is the most widely used
vaccine in the world. In addition to its effects against tuberculosis, BCG vaccination also …

BCG vaccination scar associated with better childhood survival in Guinea-Bissau

A Roth, P Gustafson, A Nhaga, Q Djana… - International journal …, 2005 - academic.oup.com
Background Recent studies have suggested that Bacille Calmette–Guerin (BCG)
vaccination may have a non-specific beneficial effect on infant survival and that a BCG scar …

Acute lower respiratory infection among Bacille Calmette-Guérin (BCG)–vaccinated children

MG Hollm-Delgado, EA Stuart, RE Black - Pediatrics, 2014 - publications.aap.org
OBJECTIVE: To determine whether Bacille Calmette-Guerin (BCG) vaccination is linked to
the risk of acute lower respiratory infection (ALRI) among children< 5 years of age …

Non-specific effect of Bacille Calmette-Guerin vaccine on the immune response to routine immunisations

N Ritz, M Mui, A Balloch, N Curtis - Vaccine, 2013 - Elsevier
Bacille Calmette-Guérin (BCG) is one of the most commonly administered vaccines
worldwide. In addition to protection against tuberculosis (TB), evidence suggests that BCG …

Infant mortality due to acute respiratory infections: the influence of primary care processes

R Hortensia, R Perez-Cuevas… - Health policy and …, 1997 - academic.oup.com
A population-based case control study was conducted to ascertain whether the process of
primary care can be a determinant of infant mortality due to Acute Respiratory Infection …

Tuberculin reaction, BCG scar, and lower female mortality

A Roth, M Sodemann, H Jensen, A Poulsen… - …, 2006 - journals.lww.com
Background: Recent studies have suggested that bacille Calmette-Guérin (BCG)
immunization may have a nonspecific beneficial effect on infant survival and that the effect …