Polyamines (putrescine, spermidine and spermine) are essential for normal cell growth. The
polyamine levels in cells are regulated by biosynthesis, degradation, and transport …

Reactive oxygen species are widely generated in biological systems. Consequently humans
have evolved antioxidant defence systems that limit their production. Intracellular production …

Immunotherapy has revolutionized outcomes for cancer patients, but the mechanisms of
resistance remain poorly defined. We used a series of whole-genome clustered regularly …

Polyamines are essential for the growth and function of normal cells. They interact with
various macromolecules, both electrostatically and covalently and, as a consequence, have …

Out of the almost 17 members of the TNF superfamily, TNF is probably the most potent
inducer of apoptosis. TNF activates both cell-survival and cell-death mechanisms …

Polyamines, consisting of putrescine, spermidine and spermine are essential for normal cell
growth and viability in eukaryotic cells. Since polyamines are cations, they interact with DNA …

Oxidative stress can be defined as the imbalance between cellular oxidant species
production and antioxidant capability. Reactive oxygen species (ROS) are involved in a …

The natural polyamines putrescine, spermidine and spermine are in multiple ways involved
in cell growth and the maintenance of cell viability. In the course of the last 15 years more …

Functional research of retinal pigment epithelium (RPE) most often relies on utilization of
RPE-derived cell lines in vitro. However, no studies about similarities and differences of the …

The natural polyamines (putrescine, spermidine and spermine) are ubiquitous low-
molecular aliphatic amines that play multifunctional roles in cell growth and differentiation …