The lysosomal degradation pathway of autophagy plays a fundamental role in cellular,
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …

Autophagy causes the breakdown of damaged proteins and organelles to their constituent
components. The phosphatidylinositol 3‐kinase (PI3K) pathway played an important role in …

Increasing clinical evidence has demonstrated that the deletion or mutation of tumor
suppressor genes such as the gene-encoding phosphatase and tensin homolog deleted on …

Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …

Endogenic tumor chemodynamic therapy (CDT) is emerging as a tumor‐therapeutic strategy
featuring in situ treatments with high efficiency and specificity based on the Fenton reaction …

Transmembrane ATPases are membrane-bound enzyme complexes and ion transporters
that can be divided into F-, V-, and A-ATPases according to their structure. The V-ATPases …

Autophagy is a highly conserved catabolic process seen in eukaryotes and is essentially a
lysosome-dependent protein degradation pathway. The dysregulation of autophagy is often …

Lung cancer often has a poor prognosis, with brain metastases a major reason for mortality.
We modified lonidamine (LND), an antiglycolytic drug with limited efficacy, to mitochondria …

Osteosarcoma, an aggressive malignant cancer, has a high lung metastasis rate and lacks
therapeutic target. Here, we reported that chromobox homolog 4 (CBX4) was overexpressed …

Alternative splicing is a critical process to generate protein diversity. However, whether and
how alternative splicing regulates autophagy remains largely elusive. Here we …