Metastasis causes most cancer-related deaths; however, the efficacy of anti-metastatic drugs
is limited by incomplete understanding of the biological mechanisms that drive metastasis …

The cascade of metastasis in tumor cells, exhibiting organ-specific tendencies, may occur at
numerous phases of the disease and progress under intense evolutionary pressures. Organ …

The interplay between genetic transformations, biochemical communications, and physical
interactions is crucial in cancer progression. Metastasis, a leading cause of cancer-related …

Crossing the vascular endothelium is a necessary stage for circulating cells aiming to reach
distant organs. Leukocyte passage through the endothelium, known as transmigration, is a …

Triple-negative breast cancer (TNBC) stands as the breast cancer subtype with the highest
recurrence and mortality rates, with the lungs being the common site of metastasis. The …

The remarkable contractility and force generation ability exhibited by cancer cells empower
them to overcome the resistance and steric hindrance presented by a three-dimensional …

In vitro vascularized cancer models utilizing microfluidics have emerged as a promising tool
for mechanism study and drug screening. However, the lack of consideration and …

Cancer-associated fibroblasts (CAFs) play a major role in reorganizing the physical tumor
micro-environment and changing tissue stiffness. Herein, using an engineered three …

The dissemination of protozoan and metazoan parasites through host tissues is hindered by
cellular barriers, dense extracellular matrices, and fluid forces in the bloodstream. To …

Vascularization is driven by morphogen signals and mechanical cues that coordinately
regulate cellular force generation, migration, and shape change to sculpt the developing …