Aquaporins function as water and neutral solute channels, signaling hubs, disease virulence
factors, and metabolon components. We consider plant aquaporins that transport ions …

Cells shield organelles and the cytosol via an active boundary predominantly made of
phospholipids and membrane proteins, yet allowing communication between the …

The water permeability of aquaporins (AQPs) varies by more than an order of magnitude
even though the pore structure, geometry, as well as the channel lining residues are highly …

Facilitated water permeation through narrow biological channels is fundamental for all forms
of life. Despite its significance in health and disease as well as for biotechnological …

Membrane proteins can be regulated by alterations in material properties intrinsic to the
hosting lipid bilayer. Here, we investigated whether the reversible photoisomerization of …

Evolution turned aquaporins (AQPs) into the most efficient facilitators of passive water flow
through cell membranes at no expense of solute discrimination. In spite of a plethora of …

The chase toward endowing chemical compounds with machine-like functions mimicking
those of biological molecular machineries has yielded a variety of artificial molecular motors …

Background Lipid-protein interactions stabilize protein oligomers, shape their structure, and
modulate their function. Whereas in vitro experiments already account for the functional …

The endeavors to understand the determinants of water permeation through membrane
channels, the effect of the lipid or polymer membrane on channel function, the development …

Understanding the determinants of permeability and selectivity in biological channels serves
two general purposes. It provides fundamental biophysical insights and allows the …