Calcium controls many critical events in the complex life cycles of apicomplexan parasites
including protein secretion, motility, and development. Calcium levels are normally tightly …

Pyrimidine ring and its fused derivatives including pyrazolo [3, 4-d] pyrimidine, pyrido [2, 3-d]
pyrimidine, quinazoline, and furo [2, 3-d] pyrimidine compounds had received much interest …

A role for B-cell-receptor (BCR) signalling in lymphomagenesis has been inferred by
studying immunoglobulin genes in human lymphomas, and by engineering mouse models …

Mitochondria have long been implicated in the pathogenesis of Parkinson's disease (PD).
Mutations in the mitochondrial kinase PINK1 that reduce kinase activity are associated with …

Abstract Cyclin-dependent kinase 12 (CDK12) phosphorylates the carboxyl-terminal domain
(CTD) of RNA polymerase II (pol II) but its roles in transcription beyond the expression of …

Meiotic gene expression in budding yeast is tightly controlled by RNA-binding proteins
(RBPs), with the meiosis-specific RBP Rim4 playing a key role in sequestering mid-late …

The Saccharomyces cerevisiae kinase Bur1 is involved in coupling transcription elongation
to chromatin modification, but not all important Bur1 targets in the elongation complex are …

As the new millennium began, CDK12 and CDK13 were discovered as nucleotide
sequences that encode protein kinases related to cell cycle CDKs. By the end of the first …

Selective autophagy eliminates protein aggregates, damaged organelles, and other targets
that otherwise accumulate and cause disease. Autophagy receptors mediate selectivity by …

Abstract p38α mitogen-activated protein kinase (p38α) is activated by a variety of
mechanisms, including autophosphorylation initiated by TGFβ-activated kinase 1 binding …