The complement cascade is an important arm of the immune system that plays a key role in
protecting the central nervous system (CNS) from infection. Recently, it has also become …

Healthy fetal development is dependent on nutrient and oxygen transfer via the placenta.
Optimal growth and function of placental vasculature is therefore essential to support in …

Current evidence indicates that certain immune molecules such as components of the
complement system are directly involved in neurobiological processes related to brain …

The complement cascade was identified over 100 years ago, yet investigation of its role in
pregnancy remains an area of intense research. Complement inhibitors at the maternal-fetal …

The early to middle childhood years are a critical period for child neurodevelopment.
Nutritional deficiencies, infection, and inflammation are major contributors to impaired child …

Background Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine–
pyrimethamine (SP), provided as part of routine antenatal care (ANC), is one of three …

Background An association between neuroinflammation, reduced adult neurogenesis, and
cognitive impairment has been established in sleep deprivation (SD). Complement …

The complement system, typically associated with innate immunity, is emerging as a key
controller of nonimmune systems including in development, with recent studies linking …

Typical of tropical and subtropical regions, malaria is caused by protozoa of the genus
Plasmodium and is, still today, despite all efforts and advances in controlling the disease, a …

As part of the innate immune system, complement plays a critical role in the elimination of
pathogens and mobilization of cellular immune responses. In the central nervous system …