Modern societies are experiencing an increasing trend of reduced sleep duration, with
nocturnal sleeping time below the recommended ranges for health. Epidemiological and …

We review theoretical and numerical models of the glymphatic system, which circulates
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …

Alzheimer disease (AD) accounts for 60–70% of dementia cases. Given the seriousness of
the disease and continual increase in patient numbers, developing effective therapies to …

Sleep-immune interactions are well-known phenomena in everyday life and folk wisdom.
There is no doubt that an infection makes us tired and increases the desire to sleep, and a …

Perivascular spaces include a variety of passageways around arterioles, capillaries and
venules in the brain, along which a range of substances can move. Although perivascular …

Brain accumulation of the amyloid-β (Aβ) peptide is believed to be the initial event in the
Alzheimer disease (AD) process. Aβ accumulation begins 15–20 years before clinical …

Background The glymphatic (glial-lymphatic) pathway is a fluid-clearance pathway identified
in the rodent brain in 2012. This pathway subserves the flow of CSF into the brain along …

Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …

As we age, we experience changes in our nighttime sleep and daytime wakefulness.
Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems even before …

Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however,
circadian rhythm disruptions are more severe in people with age-related neurodegenerative …