The RAS genes are critical oncogenic drivers activated by point mutation in some 20% of
human malignancies. However, no pharmacologic approaches to targeting RAS proteins …

Purpose: Cancer is a multigene disease which arises as a result of mutational and
epigenetic changes coupled with activation of complex signaling networks. The use of …

Although PARP inhibitors (PARPi) target homologous recombination defective tumours,
drug resistance frequently emerges, often via poorly understood mechanisms. Here, using …

Small-molecule inhibitors of PARP1/2, such as olaparib, have been proposed to serve as a
synthetic lethal therapy for cancers that harbor BRCA1 or BRCA2 mutations. Indeed, in …

X-chromosome inactivation is the process that evolved in mammals to equalize levels of X-
linked gene expression in XX females relative to XY males. Silencing of a single X …

Abstract Models derived from human pluripotent stem cells that accurately recapitulate
neural development in vitro and allow for the generation of specific neuronal subtypes are of …

Epithelial ovarian cancer (EOC) is hallmarked by a high degree of heterogeneity. To
address this heterogeneity, a classification scheme was developed based on gene …

Accumulation of senescent cells during aging contributes to chronic inflammation and age-
related diseases. While senescence is associated with profound alterations of the …

G-quadruplexes (G4) are alternative nucleic acid structures involved in transcription,
translation and replication. Aberrant G4 formation and stabilisation is linked to genome …

We describe a universal sample multiplexing method for single-cell RNA sequencing in
which fixed cells are chemically labeled by attaching identifying DNA oligonucleotides to …