Dual or multi-targeting inhibitors: The next generation anticancer agents
NM Raghavendra, D Pingili, S Kadasi, A Mettu… - European journal of …, 2018 - Elsevier
Dual-targeting/Multi-targeting of oncoproteins by a single drug molecule represents an
efficient, logical and alternative approach to drug combinations. An increasing interest in this …
efficient, logical and alternative approach to drug combinations. An increasing interest in this …
Limonoids from neem (Azadirachta indica A. Juss.) are potential anticancer drug candidates
Abstract Neem (Azadirachta indica A. Juss.), a versatile evergreen tree recognized for its
ethnopharmacological value, is a rich source of limonoids of the triterpenoid class, endowed …
ethnopharmacological value, is a rich source of limonoids of the triterpenoid class, endowed …
[HTML][HTML] Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury
D Li, W Ren, Z Jiang, L Zhu - Molecular medicine …, 2018 - spandidos-publications.com
Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) is characterized by
uncontrolled progressive lung inflammation. Macrophages serve a key role in the …
uncontrolled progressive lung inflammation. Macrophages serve a key role in the …
Research progress of meliaceous limonoids from 2011 to 2021
J Luo, Y Sun, Q Li, L Kong - Natural Product Reports, 2022 - pubs.rsc.org
Covering: July 2010 to December 2021 Limonoids, a kind of natural tetranortriterpenoids
with diverse skeletons and valuable insecticidal and medicinal bioactivities, are the …
with diverse skeletons and valuable insecticidal and medicinal bioactivities, are the …
Recent advances in the molecular mechanisms underlying pyroptosis in sepsis
YL Gao, JH Zhai, YF Chai - Mediators of inflammation, 2018 - Wiley Online Library
Sepsis is recognized as a life‐threatening organ dysfunctional disease that is caused by
dysregulated host responses to infection. Up to now, sepsis still remains a dominant cause …
dysregulated host responses to infection. Up to now, sepsis still remains a dominant cause …
[HTML][HTML] Biological activities of gedunin—A limonoid from the Meliaceae family
TM Braga, L Rocha, TY Chung, RF Oliveira, C Pinho… - Molecules, 2020 - mdpi.com
Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly
in seeds. Several biological activities have been attributed to gedunin, including …
in seeds. Several biological activities have been attributed to gedunin, including …
[HTML][HTML] Procyanidin A1 Alleviates Inflammatory Response induced by LPS through NF-κB, MAPK, and Nrf2/HO-1 Pathways in RAW264. 7 cells
S Han, H Gao, S Chen, Q Wang, X Li, LJ Du, J Li… - Scientific reports, 2019 - nature.com
Inflammation is a complex physiological process that poses a serious threat to people's
health. However, the potential molecular mechanisms of inflammation are still not clear …
health. However, the potential molecular mechanisms of inflammation are still not clear …
Natural heat shock protein 90 inhibitors in cancer and inflammation
Heat shock protein (HSP) 90 is the most abundant HSPs, which are chaperone molecules
whose major roles are cell protection and maintenance by means of aiding the folding, the …
whose major roles are cell protection and maintenance by means of aiding the folding, the …
[HTML][HTML] Anti-Inflammatory Activity of Three Triterpene from Hippophae rhamnoides L. in Lipopolysaccharide-Stimulated RAW264.7 Cells
Y Han, C Yuan, X Zhou, Y Han, Y He, J Ouyang… - International Journal of …, 2021 - mdpi.com
Oleanolic acid (OA), asiatic acid (AA), and maslinic acid (MA) are ubiquitous isomeric
triterpene phytochemicals with many pharmacological effects. To improve their application …
triterpene phytochemicals with many pharmacological effects. To improve their application …
Dihydrotanshinone exhibits an anti-inflammatory effect in vitro and in vivo through blocking TLR4 dimerization
R Yuan, L Huang, LJ Du, JF Feng, J Li, YY Luo… - Pharmacological …, 2019 - Elsevier
Dihydrotanshinone (DHT), one of the major ingredients of Salvia miltiorrhiza Bunge
(Danshen), displays many bioactivities. However, the activity and underlying mechanism of …
(Danshen), displays many bioactivities. However, the activity and underlying mechanism of …