Dual-targeting/Multi-targeting of oncoproteins by a single drug molecule represents an
efficient, logical and alternative approach to drug combinations. An increasing interest in this …

Abstract Neem (Azadirachta indica A. Juss.), a versatile evergreen tree recognized for its
ethnopharmacological value, is a rich source of limonoids of the triterpenoid class, endowed …

Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) is characterized by
uncontrolled progressive lung inflammation. Macrophages serve a key role in the …

Covering: July 2010 to December 2021 Limonoids, a kind of natural tetranortriterpenoids
with diverse skeletons and valuable insecticidal and medicinal bioactivities, are the …

Sepsis is recognized as a life‐threatening organ dysfunctional disease that is caused by
dysregulated host responses to infection. Up to now, sepsis still remains a dominant cause …

Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly
in seeds. Several biological activities have been attributed to gedunin, including …

Inflammation is a complex physiological process that poses a serious threat to people's
health. However, the potential molecular mechanisms of inflammation are still not clear …

Heat shock protein (HSP) 90 is the most abundant HSPs, which are chaperone molecules
whose major roles are cell protection and maintenance by means of aiding the folding, the …

Oleanolic acid (OA), asiatic acid (AA), and maslinic acid (MA) are ubiquitous isomeric
triterpene phytochemicals with many pharmacological effects. To improve their application …

Dihydrotanshinone (DHT), one of the major ingredients of Salvia miltiorrhiza Bunge
(Danshen), displays many bioactivities. However, the activity and underlying mechanism of …