MYC and MYCN have been directly implicated in the transcriptional regulation of several
thousand genes in pluripotent stem cells and possibly contribute to the activity of all …

Human embryonic stem cells (hESCs) and induced pluripotent stem cells proliferate rapidly
and divide symmetrically producing equivalent progeny cells. In contrast, lineage committed …

Wnt signalling through β-catenin and the lymphoid-enhancing factor 1/T-cell factor
(LEF1/TCF) family of transcription factors maintains stem cell properties in both normal and …

Activation of c-MYC is an oncogenic hallmark of many cancers, including liver cancer, and is
associated with a variety of adverse prognostic characteristics. Despite a causative role …

PSCs (pluripotent stem cells) possess two key properties that have made them the focus of
global research efforts in regenerative medicine: they have unlimited expansion potential …

Myc family members are critical to maintain embryonic stem cells (ESC) in the
undifferentiated state. However, the mechanism by which they perform this task has not yet …

Cell division is a fundamental cellular process and the evolutionarily conserved networks
that control cell division cycles adapt during development, tissue regeneration, cell de …

Pluripotent stem cells (PSCs) are defined by their self-renewal potential, which permits their
unlimited propagation, and their pluripotency, being able to generate cell of the three …

The dependence of cancer on overexpressed c-MYC and its predisposition for polyploidy
represents a double puzzle. We address this conundrum by cross-species transcription …

Fifteen years ago, we reported that proto-oncogene MYC promoted differentiation of human
epidermal stem cells, a finding that was surprising to the MYC and the skin research …