The classical studies of nicotine by Langley at the turn of the 20th century introduced the
concept of a “receptive substance,” from which the idea of a “receptor” came to light …

Rationale This review provides insight for the judicious selection of nicotine dose ranges
and routes of administration for in vivo studies. The literature is replete with reports in which …

Despite the wide-ranging and authoritative 1988 review by the US Surgeon General, views
questioning the addictiveness of nicotine contine to be expressed in some quarters. This …

OBJECTIVES It has been assumed that nicotine dependence has a slow onset and occurs
only after prolonged daily use of tobacco. A cohort of young adolescents was followed to …

The subunit composition and pharmacological regulation of rat neuronal nicotinic
cholinergic receptors were assessed. Specific immunoprecipitation was determined in …

In a postmortem study of nicotinic receptors in human brain, cigarette smoking was found to
be associated with increased (−)‐[3H] nicotine binding to membranes prepared from gyrus …

Objective: To determine if there is a minimum duration, frequency or quantity of tobacco use
required to develop symptoms of dependence. Design and setting: A retrospective …

Widely expressed in the brain, the α4β2 nicotinic acetylcholine receptor (nAChR) is
proposed to play a major role in the mechanisms that lead to and maintain nicotine …

Nicotinic acetylcholine receptors have been found to be important for maintaining optimal
performance on a variety of cognitive tasks. In humans, nicotine-induced improvement of …

The influence of α and β subunits on the properties of nicotine-induced activation and
desensitization of neuronal nicotinic acetylcholine receptors (nAChRs) expressed in …