The mammalian or mechanistic target of rapamycin (mTOR) pathway plays a crucial role in
regulation of cell survival, metabolism, growth and protein synthesis in response to upstream …

The target of rapamycin (TOR) is a highly conserved serine/threonine kinase and a central
controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in …

In KRAS-mutant lung adenocarcinoma, tumors with LKB1 loss (KL) are highly enriched for
concurrent KEAP1 mutations, which activate the KEAP1/NRF2 pathway (KLK). Here, we …

The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are
aggressive and respond poorly to standard therapies. Although the identification of specific …

Constitutive Kras and NF-κB activation is identified as signature alterations in pancreatic
ductal adenocarcinoma (PDAC). However, how NF-κB is activated in PDAC is not yet …

Lung cancer is the leading cause of cancer mortality in the United States and worldwide.
Previously, lung cancer was simplistically divided into non–small-cell lung cancer (NSCLC) …

Abstract Treatment outcomes in advanced or metastatic non-small-cell lung cancer (NSCLC)
remain unsatisfactory, with low long-term survival rates. Palliative chemotherapy offers a …

Lung cancer remains the leading cause of cancer-related deaths worldwide. However,
significant progress has been made individualizing therapy based on molecular aberrations …

Constitutive activation of the KRAS oncogene in human malignancies is associated with
aggressive tumor growth and poor prognosis. Similar to other oncogenes, KRAS acts in a …

In response to a variety of cancer-inducing stresses, cells may engage a stable cell cycle
arrest mechanism, termed cellular senescence, to suppress the proliferation of preneoplastic …