Worldwide emergence of fluconazole-resistant Candida parapsilosis: current framework and future research roadmap

F Daneshnia, JN de Almeida Júnior, M Ilkit… - The Lancet …, 2023 - thelancet.com
Candida parapsilosis is one of the most commen causes of life-threatening candidaemia,
particularly in premature neonates, individuals with cancer of the haematopoietic system …

Fluconazole resistance in Candida species: a current perspective

EL Berkow, SR Lockhart - Infection and drug resistance, 2017 - Taylor & Francis
Candida albicans and the emerging non-albicans Candida spp. have significant clinical
relevance among many patient populations. Current treatment guidelines include …

Azole Antifungal Resistance in Candida albicans and Emerging Non-albicans Candida Species

SG Whaley, EL Berkow, JM Rybak… - Frontiers in …, 2017 - frontiersin.org
Within the limited antifungal armamentarium, the azole antifungals are the most frequent
class used to treat Candida infections. Azole antifungals such as fluconazole are often …

Candida parapsilosis: from genes to the bedside

R Tóth, J Nosek, HM Mora-Montes… - Clinical microbiology …, 2019 - Am Soc Microbiol
Patients with suppressed immunity are at the highest risk for hospital-acquired infections.
Among these, invasive candidiasis is the most prevalent systemic fungal nosocomial …

Antifungal therapy: new advances in the understanding and treatment of mycosis

L Scorzoni, ACA de Paula e Silva, CM Marcos… - Frontiers in …, 2017 - frontiersin.org
The high rates of morbidity and mortality caused by fungal infections are associated with the
current limited antifungal arsenal and the high toxicity of the compounds. Additionally …

Candida Infections and Therapeutic Strategies: Mechanisms of Action for Traditional and Alternative Agents

GC de Oliveira Santos, CC Vasconcelos… - Frontiers in …, 2018 - frontiersin.org
The Candida genus comprises opportunistic fungi that can become pathogenic when the
immune system of the host fails. Candida albicans is the most important and prevalent …

Evolutionary Emergence of Drug Resistance in Candida Opportunistic Pathogens

E Ksiezopolska, T Gabaldón - Genes, 2018 - mdpi.com
Fungal infections, such as candidiasis caused by Candida, pose a problem of growing
medical concern. In developed countries, the incidence of Candida infections is increasing …

An Update on Candida tropicalis Based on Basic and Clinical Approaches

DL Zuza-Alves, WP Silva-Rocha… - Frontiers in …, 2017 - frontiersin.org
Candida tropicalis has emerged as one of the most important Candida species. It has been
widely considered the second most virulent Candida species, only preceded by C. albicans …

The quiet and underappreciated rise of drug-resistant invasive fungal pathogens

A Arastehfar, C Lass-Flörl, R Garcia-Rubio… - Journal of Fungi, 2020 - mdpi.com
Human fungal pathogens are attributable to a significant economic burden and mortality
worldwide. Antifungal treatments, although limited in number, play a pivotal role in …

[HTML][HTML] How to interpret MICs of antifungal compounds according to the revised clinical breakpoints v. 10.0 European committee on antimicrobial susceptibility testing …

MC Arendrup, N Friberg, M Mares, G Kahlmeter… - Clinical Microbiology …, 2020 - Elsevier
Background EUCAST has revised the definition of the susceptibility category I from
'Intermediate'to 'Susceptible, Increased exposure'. This implies that I can be used where the …