Type I polyketide synthases (T1PKSs) hold enormous potential as a rational production
platform for the biosynthesis of specialty chemicals. However, despite great progress in this …

Producing recombinant proteins is a major accomplishment of biotechnology in the past
century. Heterologous hosts, either eukaryotic or prokaryotic, are used for the production of …

The copy number of a plasmid is linked to its functionality, yet there have been few attempts
to optimize higher-copy-number mutants for use across diverse origins of replication in …

Horizontal gene transfer (HGT) is a major process by which genes are transferred between
microbes in the rhizosphere. However, examining HGT remains challenging due to the …

Members of Agrobacterium are costly plant pathogens while also essential tools for plant
transformation. Though Agrobacterium-mediated transformation (AMT) has been heavily …

Finding novel promoter sequences is a cornerstone of synthetic biology. To contribute to the
expanding catalog of biological parts, we employed a promoter-trap approach to identify …

Inter-laboratory replicability is crucial yet challenging in microbiome research. Leveraging
microbiomes to promote soil health and plant growth requires understanding underlying …

Recent research endeavors have turned to sustainably generating useful chemicals from
biological platforms. However, conventional model organisms, such as Escherichia coli and …

One of the largest and longest standing societal challenges is acquiring enough food to
support the human population. Our current era has the added complexities of the population …

Angesichts ihrer rationalen Architektur sind Typ-I-Polyketid-Synthasen (T1PKSs) eine
vielversprechende Plattform für Retrobiosynthese-Ansätze. Ganze Module oder einzelne …