Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease
Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …
Basal Ganglia disorders associated with imbalances in the striatal striosome and matrix compartments
JR Crittenden, AM Graybiel - Frontiers in neuroanatomy, 2011 - frontiersin.org
The striatum is composed principally of GABAergic, medium spiny striatal projection neurons
(MSNs) that can be categorized based on their gene expression, electrophysiological …
(MSNs) that can be categorized based on their gene expression, electrophysiological …
The pharmacology of L-DOPA-induced dyskinesia in Parkinson's disease
Abstract l-3, 4-Dihydroxyphenylalanine (l-DOPA) remains the most effective symptomatic
treatment of Parkinson's disease (PD). However, long-term administration of l-DOPA is …
treatment of Parkinson's disease (PD). However, long-term administration of l-DOPA is …
The 6-hydroxydopamine model of Parkinson's disease
N Simola, M Morelli, AR Carta - Neurotoxicity research, 2007 - Springer
Abstract The neurotoxin 6-hydroxydopamine (6-OHDA) continues to constitute a valuable
topical tool used chiefly in modeling Parkinson's disease in the rat. The classical method of …
topical tool used chiefly in modeling Parkinson's disease in the rat. The classical method of …
Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum
Given that cocaine induces neuroadaptations through regulation of gene expression, we
investigated whether chromatin remodeling at specific gene promoters may be a key …
investigated whether chromatin remodeling at specific gene promoters may be a key …
Regulation of gene expression and cocaine reward by CREB and ΔFosB
CA McClung, EJ Nestler - Nature neuroscience, 2003 - nature.com
ΔFosB (a truncated form of FosB) and CREB (cAMP response element binding protein) are
transcription factors induced in the brain's reward pathways after chronic exposure to drugs …
transcription factors induced in the brain's reward pathways after chronic exposure to drugs …
[HTML][HTML] Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice
A genetically valid animal model could transform our understanding of schizophrenia (SCZ)
disease mechanisms. Rare heterozygous loss-of-function (LoF) mutations in GRIN2A …
disease mechanisms. Rare heterozygous loss-of-function (LoF) mutations in GRIN2A …
[HTML][HTML] Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disorders
VK Ramanan, AJ Saykin - American journal of neurodegenerative …, 2013 - ncbi.nlm.nih.gov
The discovery of causative genetic mutations in affected family members has historically
dominated our understanding of neurodegenerative diseases such as Alzheimer's disease …
dominated our understanding of neurodegenerative diseases such as Alzheimer's disease …
Animal models of neurological deficits: how relevant is the rat?
Animal models of neurological deficits are essential for the assessment of new therapeutic
options. It has been suggested that rats are not as appropriate as primates for the …
options. It has been suggested that rats are not as appropriate as primates for the …
L-DOPA-induced dyskinesia in the intrastriatal 6-hydroxydopamine model of parkinson's disease: relation to motor and cellular parameters of nigrostriatal function
In order to assess the role of striatal dopamine (DA) afferents in l-DOPA-induced dyskinesia,
we have studied a large series of rats sustaining 2, 3, or 4 unilateral injections of 6 …
we have studied a large series of rats sustaining 2, 3, or 4 unilateral injections of 6 …