DNA methylation patterns are disrupted in various malignancies, suggesting a role in the
development of cancer, but genetic aberrations directly linking the DNA methylation …

A DNA sequence is the hard copy of the human genome and it is a driving force in
determining the physiological processes in an organism. Concurrently, the chemical …

Comprehensive studies have shown that DNA methylation plays vital roles in both loss of
pluripotency and governance of the transcriptome during embryogenesis and subsequent …

Major psychiatric disorders such as schizophrenia (SZ) and bipolar disorder (BP) with
psychosis (BP+) express a complex symptomatology characterized by positive symptoms …

DNA methylation is a prevalent epigenetic modification involved in transcriptional regulation
and essential for mammalian development. While the genome‐wide distribution of this mark …

Promoter DNA methylation is a key epigenetic mechanism for stable gene silencing, but is
correlated with expression when located in gene bodies. Maintenance and de novo DNA …

Complex biological processes, such as organogenesis and homeostasis, are stringently
regulated by genetic programs that are fine-tuned by epigenetic factors to establish cell fates …

In recent years, the notion of “one gene makes one protein that functions in one signaling
pathway” in mammalian cells has been shown to be overly simplistic. Recent genome-wide …

There is increasing evidence for the presence of an alternative code imprinted in the
genome that might contribute to gene expression regulation through an indirect reading …

The aberrant methylation of CpG island promoters of selected genes is the prominent
epigenetic mechanism by which gene transcription can be effectively silenced. Aberrant …