In the past decade, substantial advances have been made in understanding the biology of
tumour-associated macrophages (TAMs), and their clinical relevance is emerging. A …

Tumours are surrounded by a host immune system that can suppress or promote tumour
growth. The tumour microenvironment (TME) has often been framed as a singular entity …

T cell exhaustion is a major impediment to antitumor immunity. However, it remains elusive
how other immune cells in the tumor microenvironment (TME) contribute to this dysfunctional …

Despite the clinical success of checkpoint inhibitors, a substantial gap still exists in our
understanding of their mechanism of action. While antibodies to cytotoxic T lymphocyte …

Tissue-resident macrophages adapt to local signals within tissues to acquire specific
functions. Neoplasia transforms the tissue, raising the question as to how the environmental …

Tissue repair responses in metazoans are highly coordinated by different cell types over
space and time. However, comprehensive single-cell-based characterization covering this …

Abstract Interleukin-23 (IL-23) is a proinflammatory cytokine mainly produced by myeloid
cells that promotes tumor growth in various preclinical cancer models and correlates with …

Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive sarcoma, and a
lethal neurofibromatosis type 1-related malignancy, with little progress made on treatment …

Bilateral vestibular schwannoma is the hallmark of NF2-related schwannomatosis, a rare
tumour predisposition syndrome associated with a lifetime of surgical interventions …

The clinical management of advanced malignancies of the upper and lower urinary tract has
been revolutionized with the advent of immune checkpoint blockers (ICBs). ICBs reinstate or …