Positive selection drives the adaptive evolution of mitochondrial antiviral signaling (MAVS) proteins-mediating innate immunity in mammals

HI Ahmad, G Afzal, MN Iqbal, MA Iqbal… - Frontiers in Veterinary …, 2022 - frontiersin.org
The regulated production of filamentous protein complexes is essential in many biological
processes and provides a new paradigm in signal transmission. The mitochondrial antiviral …

In Silico Structural, Functional, and Phylogenetic Analysis of Cytochrome (CYPD) Protein Family

HI Ahmad, G Afzal, A Jamal, S Kiran… - BioMed Research …, 2021 - Wiley Online Library
Cytochrome (CYP) enzymes catalyze the metabolic reactions of endogenous and
exogenous compounds. The superfamily of enzymes is found across many organisms …

[Retracted] Computational Insights into the Structural and Functional Impacts of nsSNPs of Bone Morphogenetic Proteins

HI Ahmad, N Ijaz, G Afzal, AR Asif… - BioMed Research …, 2022 - Wiley Online Library
BMPs (bone morphogenetic proteins) are multipurpose (transforming growth factor) TGF‐
superfamily released cytokines. These glycoproteins, acting as disulfide‐linked homo‐or …

Structural and Phylogenetic Analysis of CXCR4 Protein Reveals New Insights into Its Role in Emerging and Re-Emerging Diseases in Mammals

F Naheed, R Mumtaz, S Shabbir, A Jamil, AR Asif… - Vaccines, 2023 - mdpi.com
Chemokine receptor type 4 (CXCR4) is a G protein-coupled receptor that plays an essential
role in immune system function and disease processes. Our study aims to conduct a …

[PDF][PDF] Isolation and characterization of nprB, a novel protease from Streptomyces thermovulgaris.

A Mushtaq, TM Ansari, G Mustafa… - Pakistan Journal of …, 2020 - researchgate.net
Bacterial proteases are of great pharmaceutical importance and have a key role in various
biological processes and in life cycle of several pathogens. New technology used for …

Structural and Functional Annotation of Napin-Like Protein from Momordica charantia to Explore its Medicinal Importance

R Arif, MA Zia, G Mustafa - Biochemical Genetics, 2022 - Springer
Seed storage proteins not just provide essential nutritional ingredients for growth of
seedlings but also have their potential role in defense mechanisms of plants. Napin is a …

[PDF][PDF] Antiviral activity of hexapeptides derived from conserved regions of bacterial proteases against HCV NS3 protease.

A Mushtaq, G Mustafa, TM Ansari… - Pakistan Journal of …, 2021 - researchgate.net
The main cause of hepatitis C is hepatitis C virus or HCV and for the cure of hepatitis C,
NS3/4A protease has been found an important and emerging target. A number of HCV …

Phylogenetic analyses, protein modeling and active site prediction of two pathogenesis related (PR2 and PR3) genes from bread wheat

M Numan, SA Bukhari, M Rehman, G Mustafa, B Sadia - Plos one, 2021 - journals.plos.org
Wheat is a major staple food and has been extensively grown around the globe. Sessile
nature of plants has exposed them to a lot of biotic and abiotic stresses including fungal …

Genome-wide analysis of sucrose synthase family in soybean and their expression in response to abiotic stress and seed development

MZ Ahmad, HI Ahmad, A Gul, Z Shah, B Ahmad… - Plos one, 2022 - journals.plos.org
The sucrose synthase (SS) is an important enzyme family which play a vital role in sugar
metabolism to improve the fruit quality of the plants. In many plant species, the members of …

[PDF][PDF] Screening of novel phytochemicals as secreted frizzled-related protein 4 inhibitors: an early stage biomarker of type 2 diabetes

A Yasmin, SA Bukhari, MK Zahoor… - Pakistan Journal of …, 2020 - researchgate.net
Diabetes is increasing at an alarming rate worldwide with high mortality and posing severe
health and economic burden. Secreted frizzled related protein 4 (SFRP4) is released from …