Manganese plays multiple role in many biological redox reactions in which it exists in
different oxidation states from Mn (II) to Mn (IV). Among them the high-valent manganese …

Microcrystal electron diffraction (MicroED) has recently shown potential for structural biology.
It enables the study of biomolecules from micrometer-sized 3D crystals that are too small to …

Chlamydia protein associating with death domains (CADD) is involved in the biosynthesis of
para-aminobenzoate (pABA), an essential component of the folate cofactor that is required …

The tetramanganese–calcium cluster of the oxygen‐evolving complex of photosystem II
adopts electronically and magnetically distinct but interconvertible valence isomeric forms in …

Nature's water-splitting catalyst, an oxygen-bridged tetramanganese calcium (Mn4O5Ca)
complex, sequentially activates two substrate water molecules generating molecular O2. Its …

Class Ic ribonucleotide reductases (RNRIc) and R2-like ligand-binding oxidases (R2lox) are
known to contain heterobimetallic MnIIFeII cofactors. How these enzymes assemble MnIIFeII …

Traditionally, the ferritin-like superfamily of proteins was thought to exclusively use a diiron
active site in catalyzing a diverse array of oxygen-dependent reactions. In recent years …

Lipoxygenases have proven to be a potential biocatalyst for various industrial applications.
However, low catalytic activity, low thermostability, and narrow range of pH stability largely …

Heterobimetallic Mn/Fe proteins represent a new cofactor paradigm in bioinorganic
chemistry and pose countless outstanding questions. The assembly of the active site defies …

Two recently discovered groups of prokaryotic di-metal carboxylate proteins harbor a
heterodinuclear Mn/Fe cofactor. These are the class Ic ribonucleotide reductase R2 proteins …