Chalcone: a promising bioactive scaffold in medicinal chemistry
Chalcones are a class of privileged scaffolds with high medicinal significance due to the
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …
Anticancer potential of spirocompounds in medicinal chemistry: A pentennial expedition
D Bora, A Kaushal, N Shankaraiah - European Journal of Medicinal …, 2021 - Elsevier
Spirocompounds constitute an important class of organic frameworks enveloping numerous
pharmacological activities, among them, the promising anticancer potential of …
pharmacological activities, among them, the promising anticancer potential of …
Coumarin hybrid derivatives as promising leads to treat tuberculosis: Recent developments and critical aspects of structural design to exhibit anti-tubercular activity
Tuberculosis (TB) is a highly contagious airborne disease with nearly 25% of the world's
population infected with it. Challenges such as multi drug resistant TB (MDR-TB), extensive …
population infected with it. Challenges such as multi drug resistant TB (MDR-TB), extensive …
Dual target inhibitors based on EGFR: Promising anticancer agents for the treatment of cancers (2017-)
L Hu, M Fan, S Shi, X Song, F Wang, H He… - European Journal of …, 2022 - Elsevier
The EGFR family play a significant role in cell signal transduction and their overexpression
is implicated in the pathogenesis of numerous human solid cancers. Inhibition of the EGFR …
is implicated in the pathogenesis of numerous human solid cancers. Inhibition of the EGFR …
Chromone, a privileged scaffold in drug discovery: Developments in the synthesis and bioactivity
AT Benny, SD Arikkatt, CG Vazhappilly… - Mini Reviews in …, 2022 - ingentaconnect.com
Chromones are the class of secondary metabolites that broadly occur in the plant kingdom
in a noticeable quantity. This rigid bicyclic system has been categorized “as privileged …
in a noticeable quantity. This rigid bicyclic system has been categorized “as privileged …
[HTML][HTML] Antitubercular and antioxidant activities of hydroxy and chloro substituted chalcone analogues: Synthesis, biological and computational studies
S Ammaji, S Masthanamma, RR Bhandare… - Arabian Journal of …, 2022 - Elsevier
A series of chalcone analogues (1–15) were synthesized by Claisen-Schmidt condensation
in good yields (70–95%) and characterized by FT-IR, 1 H NMR and mass spectral methods …
in good yields (70–95%) and characterized by FT-IR, 1 H NMR and mass spectral methods …
Biological role of chalcones in medicinal chemistry
Chalcones are promising synthons and bioactive scaffolds of great medicinal interest due to
their numerous pharmacological and biological activities. They are well recognized to …
their numerous pharmacological and biological activities. They are well recognized to …
Accessing α-Arylated Nitriles via BF3·OEt2 Catalyzed Cyanation of para-Quinone Methides Using tert-Butyl Isocyanide as a Cyanide Source
BF3· OEt2 catalyzed 1, 6-conjugate addition of tert-butyl isocyanide to para-quinone
methides and fuchsones for the synthesis of α-diaryl and α-triaryl nitriles has been reported …
methides and fuchsones for the synthesis of α-diaryl and α-triaryl nitriles has been reported …
Design, synthesis and anticancer evaluation of novel spirobenzo [h] chromene and spirochromane derivatives with dual EGFR and B-RAF inhibitory activities
A novel series of spirobenzo [h] chromene and spirochromane derivatives was designed,
synthesized and evaluated as potential anticancer agents against MCF-7 (human breast …
synthesized and evaluated as potential anticancer agents against MCF-7 (human breast …
TiO2 Nanoparticles Immobilized on Carbon Nanotubes: An Efficient Heterogeneous Catalyst in Cyclocondensation Reaction of Isatins with Malononitrile and 4 …
S Abdolmohammadi… - Applied …, 2020 - Wiley Online Library
TiO2 nanoparticles supported on carbon nanotubes (TiO2‐CNTs) as an efficient
heterogeneous catalyst was used for the synthesis of spiro [3, 4′] 1, 3‐dihydro‐2H‐indol‐2 …
heterogeneous catalyst was used for the synthesis of spiro [3, 4′] 1, 3‐dihydro‐2H‐indol‐2 …