The teleology of sex differences has been argued since at least as early as Aristotle's
controversial Generation of Animals more than 300 years BC, which reflects the sex bias of …

Impairment of vascular function, in particular endothelial dysfunction and large elastic artery
stiffening, represents a major link between ageing and cardiovascular risk. Clinical and …

Abstract Purpose of the Review This review summarizes sex-related changes in the heart
and vasculature that occur with aging, both in the presence and absence of cardiovascular …

Background The objective of this study was to examine the correlation between serum
Klotho protein concentration and postmenopausal hypertension. Methods A cross-sectional …

The endothelin-B (ETB) receptor is a key regulator of vascular endothelial function in
women. We have previously shown that the ETB receptor mediates vasodilation in young …

Introduction Current understanding of sodium (Na+) handling is based on studies done
primarily in males. Contrary to the gradual increase in high salt (HS) induced natriuresis …

Aging is a primary risk factor for cardiovascular disease (CVD), which is the leading cause of
death in developed countries. Globally, the population of adults over the age of 60 is …

Obesity is associated with dysregulation of the endothelin system. In individuals with obesity,
an exaggerated pressor response to acute stress is accompanied by increased circulating …

Changes in endothelial function precede the development of cardiovascular disease (CVD).
We have previously shown that age-related declines in endothelial function in women are …

Klostranec et al database, Hox et al (18) used a passive systemic anaphylaxis mouse model
to test the role of estrogen in this process. They found that estradiol caused an upregulation …