We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

Unravelling the pathophysiology of depression is a unique challenge. Not only are
depressive syndromes heterogeneous and their aetiologies diverse, but symptoms such as …

Every individual experiences stressful life events. In some cases acute or chronic stress
leads to depression and other psychiatric disorders, but most people are resilient to such …

Stress is a major risk factor in the onset of several neuropsychiatric disorders including
anxiety and depression. Although several studies have shown that social isolation stress …

Much of the current understanding about the pathogenesis of altered mood, impaired
concentration and neurovegetative symptoms in major depression has come from animal …

Humans exhibit a remarkable degree of resilience in the face of extreme stress, with most
resisting the development of neuropsychiatric disorders. Over the past 5 years, there has …

Major depressive disorder is a heritable psychiatric syndrome that appears to be associated
with subtle cellular and molecular alterations in a complex neural network. The affected …

Decreased medial prefrontal cortex (mPFC) neuronal activity is associated with social defeat-
induced depression-and anxiety-like behaviors in mice. However, the molecular …

Psychological stress contributes to the development of clinical depression. This has
prompted many preclinical studies to investigate the neurobiology of this relationship …

The term “resilience” refers to the ability to adapt successfully to stress, trauma and
adversity, enabling individuals to avoid stress-induced mental disorders such as depression …