Small bioactive peptides for biomaterials design and therapeutics
IW Hamley - Chemical reviews, 2017 - ACS Publications
This review is aimed to provide a concise yet extensive survey of key short bioactive peptide
sequences for a range of applications ranging from biomaterials development to peptides …
sequences for a range of applications ranging from biomaterials development to peptides …
Cell-penetrating peptide: a means of breaking through the physiological barriers of different tissues and organs
J Xu, AR Khan, M Fu, R Wang, J Ji, G Zhai - Journal of Controlled Release, 2019 - Elsevier
The selective infiltration of cell membranes and tissue barriers often blocks the entry of most
active molecules. This natural defense mechanism prevents the invasion of exogenous …
active molecules. This natural defense mechanism prevents the invasion of exogenous …
Redesigning of cell-penetrating peptides to improve their efficacy as a drug delivery system
Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of
compounds into cells. Since the discovery of the first members of this peptide family, many …
compounds into cells. Since the discovery of the first members of this peptide family, many …
Branched BBB-shuttle peptides: chemoselective modification of proteins to enhance blood–brain barrier transport
C Díaz-Perlas, B Oller-Salvia, M Sánchez-Navarro… - Chemical …, 2018 - pubs.rsc.org
The blood–brain barrier (BBB) hampers the delivery of therapeutic proteins into the brain.
BBB-shuttle peptides have been conjugated to therapeutic payloads to increase the …
BBB-shuttle peptides have been conjugated to therapeutic payloads to increase the …
Conjugation of therapeutic psd-95 inhibitors to the cell-penetrating peptide tat affects blood–brain barrier adherence, uptake, and permeation
Novel stroke therapies are needed. Inhibition of the interaction between the postsynaptic
density-95 (PSD-95)/disc large/ZO-1 (PDZ) domains of PSD-95 and the N-methyl-D …
density-95 (PSD-95)/disc large/ZO-1 (PDZ) domains of PSD-95 and the N-methyl-D …
Anti-microRNA targeting using peptide-based nanocomplexes to inhibit differentiation of human pancreatic stellate cells
J Schnittert, PR Kuninty, TF Bystry, R Brock… - …, 2017 - Taylor & Francis
Aim: To develop novel peptide-based nanocomplexes (NCs) for delivery of anti-miRNA
oligonucleotides to human-derived pancreatic stellate cells (hPSCs), precursors of cancer …
oligonucleotides to human-derived pancreatic stellate cells (hPSCs), precursors of cancer …
The distribution of cell-penetrating peptides on polymeric nanoparticles prepared using microfluidics and elucidated with small angle X-ray scattering
Hypothesis The distribution of three cell-penetrating peptides (CPPs) with different
architectures (short, long linear and branched) on poly (lactic-co-glycolic) acid (PLGA) …
architectures (short, long linear and branched) on poly (lactic-co-glycolic) acid (PLGA) …
Bioactive clusters promoting cell penetration and nucleic acid complexation for drug and gene delivery applications: from designed to self-assembled and responsive …
Bioactive low-molecular-weight compounds are actively pursued, as an alternative to
macromolecules, for biomedical applications such as drug and gene delivery. However …
macromolecules, for biomedical applications such as drug and gene delivery. However …
Interactions of cell-penetrating peptide-modified nanoparticles with cells evaluated using single particle tracking
Cell-penetrating peptides (CPPs) are known to interact with cell membranes and by doing
so enhance cellular interaction and subsequent cellular internalization of nanoparticles. Yet …
so enhance cellular interaction and subsequent cellular internalization of nanoparticles. Yet …
Enhanced intracellular peptide delivery by multivalent cell-penetrating peptide with bioreducible linkage
H Kim, M Kitamatsu, T Ohtsuki - Bioorganic & medicinal chemistry letters, 2018 - Elsevier
Multivalent cell-penetrating peptides (CPPs) have been reported to show enhancement in
cellular uptake and endosomolytic activity. However, its application was limited to trans …
cellular uptake and endosomolytic activity. However, its application was limited to trans …